Search Results

Overview

Uniprot IDQ12789
Protein NameGeneral transcription factor 3C polypeptide 1
Gene NameGTF3C1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
121 CRYFKERKNITNDIR
1233 KKIKRKKKGEFPGEK
1242 EFPGEKSKRLRYHDE
321 HPECGPCKTKKGTDV
323 ECGPCKTKKGTDVMV
324 CGPCKTKKGTDVMVR
507 ASANLRPKTQPHHST
517 PHHSTPTKGGWKVVN
521 TPTKGGWKVVNLHPL
529 VVNLHPLKKQPPSFP
530 VNLHPLKKQPPSFPG
597 KESSSSLKTGRHSSG
770 RMKKSDNKMGITPLR

Function

Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element

Protein Sequence

10 MDALESLLDE 20 VALEGLDGLC 30 LPALWSRLET 40 RVPPFPLPLE 50 PCTQEFLWRA 60 LATHPGISFY 70 EEPRERPDLQ 80 LQDRYEEIDL 90 ETGILESRRD 100 PVALEDVYPI 110 HMILENKDGI 120 QGSCRYFKER 130 KNITNDIRTK 140 SLQPRCTMVE 150 AFDRWGKKLI 160 IVASQAMRYR 170 ALIGQEGDPD 180 LKLPDFSYCI 190 LERLGRSRWQ 200 GELQRDLHTT 210 AFKVDAGKLH 220 YHRKILNKNG 230 LITMQSHVIR 240 LPTGAQQHSI 250 LLLLNRFHVD 260 RRSKYDILME 270 KLSVMLSTRT 280 NHIETLGKLR 290 EELGLCERTF 300 KRLYQYMLNA 310 GLAKVVSLRL 320 QEIHPECGPC 330 KTKKGTDVMV 340 RCLKLLKEFK 350 RNDHDDDEDE 360 EVISKTVPPV 370 DIVFERDMLT 380 QTYDLIERRG 390 TKGISQAEIR 400 VAMNVGKLEA 410 RMLCRLLQRF 420 KVVKGFMEDE 430 GRQRTTKYIS 440 CVFAEESDLS 450 RQYQREKARS 460 ELLTTVSLAS 470 MQEESLLPEG 480 EDTFLSESDS 490 EEERSSSKRR 500 GRGSQKDTRA 510 SANLRPKTQP 520 HHSTPTKGGW 530 KVVNLHPLKK 540 QPPSFPGAAE 550 ERACQSLASR 560 DSLLDTSSVS 570 EPNVSFVSHC 580 ADSNSGDIAV 590 IEEVRMENPK 600 ESSSSLKTGR 610 HSSGQDKPHE 620 TYRLLKRRNL 630 IIEAVTNLRL 640 IESLFTIQKM 650 IMDQEKQEGV 660 STKCCKKSIV 670 RLVRNLSEEG 680 LLRLYRTTVI 690 QDGIKKKVDL 700 VVHPSMDQND 710 PLVRSAIEQV 720 RFRISNSSTA 730 NRVKTSQPPV 740 PQGEAEEDSQ 750 GKEGPSGSGD 760 SQLSASSRSE 770 SGRMKKSDNK 780 MGITPLRNYH 790 PIVVPGLGRS 800 LGFLPKMPRL 810 RVVHMFLWYL 820 IYGHPASNTV 830 EKPSFISERR 840 TIKQESGRAG 850 VRPSSSGSAW 860 EACSEAPSKG 870 SQDGVTWEAE 880 VELATETVYV 890 DDASWMRYIP 900 PIPVHRDFGF 910 GWALVSDILL 920 CLPLSIFIQI 930 VQVSYKVDNL 940 EEFLNDPLKK 950 HTLIRFLPRP 960 IRQQLLYKRR 970 YIFSVVENLQ 980 RLCYMGLLQF 990 GPTEKFQDKD 1000 QVFIFLKKNA 1010 VIVDTTICDP 1020 HYNLARSSRP 1030 FERRLYVLNS 1040 MQDVENYWFD 1050 LQCVCLNTPL 1060 GVVRCPRVRK 1070 NSSTDQGSDE 1080 EGSLQKEQES 1090 AMDKHNLERK 1100 CAMLEYTTGS 1110 REVVDEGLIP 1120 GDGLGAAGLD 1130 SSFYGHLKRN 1140 WIWTSYIINQ 1150 AKKENTAAEN 1160 GLTVRLQTFL 1170 SKRPMPLSAR 1180 GNSRLNIWGE 1190 ARVGSELCAG 1200 WEEQFEVDRE 1210 PSLDRNRRVR 1220 GGKSQKRKRL 1230 KKDPGKKIKR 1240 KKKGEFPGEK 1250 SKRLRYHDEA 1260 DQSALQRMTR 1270 LRVTWSMQED 1280 GLLVLCRIAS 1290 NVLNTKVKGP 1300 FVTWQVVRDI 1310 LHATFEESLD 1320 KTSHSVGRRA 1330 RYIVKNPQAY 1340 LNYKVCLAEV 1350 YQDKALVGDF 1360 MNRRGDYDDP 1370 KVCANEFKEF 1380 VEKLKEKFSS 1390 ALRNSNLEIP 1400 DTLQELFARY 1410 RVLAIGDEKD 1420 QTRKEDELNS 1430 VDDIHFLVLQ 1440 NLIQSTLALS 1450 DSQMKSYQSF 1460 QTFRLYREYK 1470 DHVLVKAFME 1480 CQKRSLVNRR 1490 RVNHTLGPKK 1500 NRALPFVPMS 1510 YQLSQTYYRI 1520 FTWRFPSTIC 1530 TESFQFLDRM 1540 RAAGKLDQPD 1550 RFSFKDQDNN 1560 EPTNDMVAFS 1570 LDGPGGNCVA 1580 VLTLFSLGLI 1590 SVDVRIPEQI 1600 IVVDSSMVEN 1610 EVIKSLGKDG 1620 SLEDDEDEED 1630 DLDEGVGGKR 1640 RSMEVKPAQA 1650 SHTNYLLMRG 1660 YYSPGIVSTR 1670 NLNPNDSIVV 1680 NSCQMKFQLR 1690 CTPVPARLRP 1700 AAAPLEELTM 1710 GTSCLPDTFT 1720 KLINPQENTC 1730 SLEEFVLQLE 1740 LSGYSPEDLT 1750 AALEILEAII 1760 ATGCFGIDKE 1770 ELRRRFSALE 1780 KAGGGRTRTF 1790 ADCIQALLEQ 1800 HQVLEVGGNT 1810 ARLVAMGSAW 1820 PWLLHSVRLK 1830 DREDADIQRE 1840 DPQARPLEGS 1850 SSEDSPPEGQ 1860 APPSHSPRGT 1870 KRRASWASEN 1880 GETDAEGTQM 1890 TPAKRPALQD 1900 SNLAPSLGPG 1910 AEDGAEAQAP 1920 SPPPALEDTA 1930 AAGAAQEDQE 1940 GVGEFSSPGQ 1950 EQLSGQAQPP 1960 EGSEDPRGFT 1970 ESFGAANISQ 1980 AARERDCESV 1990 CFIGRPWRVV 2000 DGHLNLPVCK 2010 GMMEAMLYHI 2020 MTRPGIPESS 2030 LLRHYQGVLQ 2040 PVAVLELLQG 2050 LESLGCIRKR 2060 WLRKPRPVSL 2070 FSTPVVEEVE 2080 VPSSLDESPM 2090 AFYEPTLDCT 2100 LRLGRVFPHE VNWNKWIHL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:1990904 ribonucleoprotein complex
Cellular Component GO:0000127 transcription factor TFIIIC complex
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0000995 RNA polymerase III general transcription initiation factor activity
Biological Process GO:0042791 5S class rRNA transcription by RNA polymerase III
Biological Process GO:0009303 rRNA transcription
Biological Process GO:0006383 transcription by RNA polymerase III
Biological Process GO:0006384 transcription initiation at RNA polymerase III promoter
Biological Process GO:0009304 tRNA transcription
Biological Process GO:0042797 tRNA transcription by RNA polymerase III

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.