Search Results

Overview

Uniprot IDQ12792
Protein NameTwinfilin-1
Gene NameTWF1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
135 DVSLHGYKKYLLSQS
136 VSLHGYKKYLLSQSS
320 HPKQHAHKQSFAKPK
325 AHKQSFAKPKGPAGK

Function

Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity)

Protein Sequence

10 MSHQTGIQAS 20 EDVKEIFARA 30 RNGKYRLLKI 40 SIENEQLVIG 50 SYSQPSDSWD 60 KDYDSFVLPL 70 LEDKQPCYIL 80 FRLDSQNAQG 90 YEWIFIAWSP 100 DHSHVRQKML 110 YAATRATLKK 120 EFGGGHIKDE 130 VFGTVKEDVS 140 LHGYKKYLLS 150 QSSPAPLTAA 160 EEELRQIKIN 170 EVQTDVGVDT 180 KHQTLQGVAF 190 PISREAFQAL 200 EKLNNRQLNY 210 VQLEIDIKNE 220 IIILANTTNT 230 ELKDLPKRIP 240 KDSARYHFFL 250 YKHSHEGDYL 260 ESIVFIYSMP 270 GYTCSIRERM 280 LYSSCKSRLL 290 EIVERQLQMD 300 VIRKIEIDNG 310 DELTADFLYE 320 EVHPKQHAHK 330 QSFAKPKGPA 340 GKRGIRRLIR 350 GPAETEATTD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005884 actin filament
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030175 filopodium
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0030016 myofibril
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0032587 ruffle membrane
Molecular Function GO:0003779 actin binding
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0003785 actin monomer binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
Biological Process GO:0030042 actin filament depolymerization
Biological Process GO:0051016 barbed-end actin filament capping
Biological Process GO:0030837 negative regulation of actin filament polymerization
Biological Process GO:0010613 positive regulation of cardiac muscle hypertrophy
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0010591 regulation of lamellipodium assembly

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.