Search Results

Overview

Uniprot ID	Q12805
Protein Name	EGF-containing fibulin-like extracellular matrix protein 1
Gene Name	EFEMP1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
429	TINTFRIKSGNENGE
56	DIVPDACKGGMKCVN
60	DACKGGMKCVNHYGG

Function

Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth

Protein Sequence

10 MLKALFLTML 20 TLALVKSQDT 30 EETITYTQCT 40 DGYEWDPVRQ 50 QCKDIDECDI 60 VPDACKGGMK 70 CVNHYGGYLC 80 LPKTAQIIVN 90 NEQPQQETQP 100 AEGTSGATTG 110 VVAASSMATS 120 GVLPGGGFVA 130 SAAAVAGPEM 140 QTGRNNFVIR 150 RNPADPQRIP 160 SNPSHRIQCA 170 AGYEQSEHNV 180 CQDIDECTAG 190 THNCRADQVC 200 INLRGSFACQ 210 CPPGYQKRGE 220 QCVDIDECTI 230 PPYCHQRCVN 240 TPGSFYCQCS 250 PGFQLAANNY 260 TCVDINECDA 270 SNQCAQQCYN 280 ILGSFICQCN 290 QGYELSSDRL 300 NCEDIDECRT 310 SSYLCQYQCV 320 NEPGKFSCMC 330 PQGYQVVRSR 340 TCQDINECET 350 TNECREDEMC 360 WNYHGGFRCY 370 PRNPCQDPYI 380 LTPENRCVCP 390 VSNAMCRELP 400 QSIVYKYMSI 410 RSDRSVPSDI 420 FQIQATTIYA 430 NTINTFRIKS 440 GNENGEFYLR 450 QTSPVSAMLV 460 LVKSLSGPRE 470 HIVDLEMLTV 480 SSIGTFRTSS 490 VLRLTIIVGP FSF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0031012	extracellular matrix
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0005006	epidermal growth factor receptor activity
Molecular Function	GO:0005154	epidermal growth factor receptor binding
Molecular Function	GO:0005201	extracellular matrix structural constituent
Molecular Function	GO:0008083	growth factor activity
Biological Process	GO:0043010	camera-type eye development
Biological Process	GO:0048048	embryonic eye morphogenesis
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway
Biological Process	GO:0032331	negative regulation of chondrocyte differentiation
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation
Biological Process	GO:0048050	post-embryonic eye morphogenesis
Biological Process	GO:0006355	regulation of DNA-templated transcription
Biological Process	GO:0007601	visual perception

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.