Search Results

Overview

Uniprot IDQ12830
Protein NameNucleosome-remodeling factor subunit BPTF
Gene NameBPTF
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1238 SPVITKAKEGCQSDS
1304 SIRSPETKCPKQNSI
1335 EPSKSKTKGNDFFID
1358 DIGTLICKNKKPLIQ
1360 GTLICKNKKPLIQEE
1500 LEERPVNKCSDQIKL
1536 STFQINGKDNKPKIY
1545 NKPKIYLKGECLKEI
1571 PKVNNINKIIPENDI
2368 TGEQRQSKLSPQMQV
2736 RSKQNATKLSALLFK
2853 SSKSKKKKMISTTSK
2860 KMISTTSKETKKDTK
489 DTENENEKKIWYYST
619 DDDPEQGKSEEPTEV
786 RLRNPDSKLSQLKSQ
791 DSKLSQLKSQQVAAA

Function

Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013)

Protein Sequence

10 MRGRRGRPPK 20 QPAAPAAERC 30 APAPPPPPPP 40 PTSGPIGGLR 50 SRHRGSSRGR 60 WAAAQAEVAP 70 KTRLSSPRGG 80 SSSRRKPPPP 90 PPAPPSTSAP 100 GRGGRGGGGG 110 RTGGGGGGGH 120 LARTTAARRA 130 VNKVVYDDHE 140 SEEEEEEEDM 150 VSEEEEEEDG 160 DAEETQDSED 170 DEEDEMEEDD 180 DDSDYPEEME 190 DDDDDASYCT 200 ESSFRSHSTY 210 SSTPGRRKPR 220 VHRPRSPILE 230 EKDIPPLEFP 240 KSSEDLMVPN 250 EHIMNVIAIY 260 EVLRNFGTVL 270 RLSPFRFEDF 280 CAALVSQEQC 290 TLMAEMHVVL 300 LKAVLREEDT 310 SNTTFGPADL 320 KDSVNSTLYF 330 IDGMTWPEVL 340 RVYCESDKEY 350 HHVLPYQEAE 360 DYPYGPVENK 370 IKVLQFLVDQ 380 FLTTNIAREE 390 LMSEGVIQYD 400 DHCRVCHKLG 410 DLLCCETCSA 420 VYHLECVKPP 430 LEEVPEDEWQ 440 CEVCVAHKVP 450 GVTDCVAEIQ 460 KNKPYIRHEP 470 IGYDRSRRKY 480 WFLNRRLIIE 490 EDTENENEKK 500 IWYYSTKVQL 510 AELIDCLDKD 520 YWEAELCKIL 530 EEMREEIHRH 540 MDITEDLTNK 550 ARGSNKSFLA 560 AANEEILESI 570 RAKKGDIDNV 580 KSPEETEKDK 590 NETENDSKDA 600 EKNREEFEDQ 610 SLEKDSDDKT 620 PDDDPEQGKS 630 EEPTEVGDKG 640 NSVSANLGDN 650 TTNATSEETS 660 PSEGRSPVGC 670 LSETPDSSNM 680 AEKKVASELP 690 QDVPEEPNKT 700 CESSNTSATT 710 TSIQPNLENS 720 NSSSELNSSQ 730 SESAKAADDP 740 ENGERESHTP 750 VSIQEEIVGD 760 FKSEKSNGEL 770 SESPGAGKGA 780 SGSTRIITRL 790 RNPDSKLSQL 800 KSQQVAAAAH 810 EANKLFKEGK 820 EVLVVNSQGE 830 ISRLSTKKEV 840 IMKGNINNYF 850 KLGQEGKYRV 860 YHNQYSTNSF 870 ALNKHQHRED 880 HDKRRHLAHK 890 FCLTPAGEFK 900 WNGSVHGSKV 910 LTISTLRLTI 920 TQLENNIPSS 930 FLHPNWASHR 940 ANWIKAVQMC 950 SKPREFALAL 960 AILECAVKPV 970 VMLPIWRESL 980 GHTRLHRMTS 990 IEREEKEKVK 1000 KKEKKQEEEE 1010 TMQQATWVKY 1020 TFPVKHQVWK 1030 QKGEEYRVTG 1040 YGGWSWISKT 1050 HVYRFVPKLP 1060 GNTNVNYRKS 1070 LEGTKNNMDE 1080 NMDESDKRKC 1090 SRSPKKIKIE 1100 PDSEKDEVKG 1110 SDAAKGADQN 1120 EMDISKITEK 1130 KDQDVKELLD 1140 SDSDKPCKEE 1150 PMEVDDDMKT 1160 ESHVNCQESS 1170 QVDVVNVSEG 1180 FHLRTSYKKK 1190 TKSSKLDGLL 1200 ERRIKQFTLE 1210 EKQRLEKIKL 1220 EGGIKGIGKT 1230 STNSSKNLSE 1240 SPVITKAKEG 1250 CQSDSMRQEQ 1260 SPNANNDQPE 1270 DLIQGCSESD 1280 SSVLRMSDPS 1290 HTTNKLYPKD 1300 RVLDDVSIRS 1310 PETKCPKQNS 1320 IENDIEEKVS 1330 DLASRGQEPS 1340 KSKTKGNDFF 1350 IDDSKLASAD 1360 DIGTLICKNK 1370 KPLIQEESDT 1380 IVSSSKSALH 1390 SSVPKSTNDR 1400 DATPLSRAMD 1410 FEGKLGCDSE 1420 SNSTLENSSD 1430 TVSIQDSSEE 1440 DMIVQNSNES 1450 ISEQFRTREQ 1460 DVEVLEPLKC 1470 ELVSGESTGN 1480 CEDRLPVKGT 1490 EANGKKPSQQ 1500 KKLEERPVNK 1510 CSDQIKLKNT 1520 TDKKNNENRE 1530 SEKKGQRTST 1540 FQINGKDNKP 1550 KIYLKGECLK 1560 EISESRVVSG 1570 NVEPKVNNIN 1580 KIIPENDIKS 1590 LTVKESAIRP 1600 FINGDVIMED 1610 FNERNSSETK 1620 SHLLSSSDAE 1630 GNYRDSLETL 1640 PSTKESDSTQ 1650 TTTPSASCPE 1660 SNSVNQVEDM 1670 EIETSEVKKV 1680 TSSPITSEEE 1690 SNLSNDFIDE 1700 NGLPINKNEN 1710 VNGESKRKTV 1720 ITEVTTMTST 1730 VATESKTVIK 1740 VEKGDKQTVV 1750 SSTENCAKST 1760 VTTTTTTVTK 1770 LSTPSTGGSV 1780 DIISVKEQSK 1790 TVVTTTVTDS 1800 LTTTGGTLVT 1810 SMTVSKEYST 1820 RDKVKLMKFS 1830 RPKKTRSGTA 1840 LPSYRKFVTK 1850 SSKKSIFVLP 1860 NDDLKKLARK 1870 GGIREVPYFN 1880 YNAKPALDIW 1890 PYPSPRPTFG 1900 ITWRYRLQTV 1910 KSLAGVSLML 1920 RLLWASLRWD 1930 DMAAKAPPGG 1940 GTTRTETSET 1950 EITTTEIIKR 1960 RDVGPYGIRS 1970 EYCIRKIICP 1980 IGVPETPKET 1990 PTPQRKGLRS 2000 SALRPKRPET 2010 PKQTGPVIIE 2020 TWVAEEELEL 2030 WEIRAFAERV 2040 EKEKAQAVEQ 2050 QAKKRLEQQK 2060 PTVIATSTTS 2070 PTSSTTSTIS 2080 PAQKVMVAPI 2090 SGSVTTGTKM 2100 VLTTKVGSPA 2110 TVTFQQNKNF 2120 HQTFATWVKQ 2130 GQSNSGVVQV 2140 QQKVLGIIPS 2150 STGTSQQTFT 2160 SFQPRTATVT 2170 IRPNTSGSGG 2180 TTSNSQVITG 2190 PQIRPGMTVI 2200 RTPLQQSTLG 2210 KAIIRTPVMV 2220 QPGAPQQVMT 2230 QIIRGQPVST 2240 AVSAPNTVSS 2250 TPGQKSLTSA 2260 TSTSNIQSSA 2270 SQPPRPQQGQ 2280 VKLTMAQLTQ 2290 LTQGHGGNQG 2300 LTVVIQGQGQ 2310 TTGQLQLIPQ 2320 GVTVLPGPGQ 2330 QLMQAAMPNG 2340 TVQRFLFTPL 2350 ATTATTASTT 2360 TTTVSTTAAG 2370 TGEQRQSKLS 2380 PQMQVHQDKT 2390 LPPAQSSSVG 2400 PAEAQPQTAQ 2410 PSAQPQPQTQ 2420 PQSPAQPEVQ 2430 TQPEVQTQTT 2440 VSSHVPSEAQ 2450 PTHAQSSKPQ 2460 VAAQSQPQSN 2470 VQGQSPVRVQ 2480 SPSQTRIRPS 2490 TPSQLSPGQQ 2500 SQVQTTTSQP 2510 IPIQPHTSLQ 2520 IPSQGQPQSQ 2530 PQVQSSTQTL 2540 SSGQTLNQVT 2550 VSSPSRPQLQ 2560 IQQPQPQVIA 2570 VPQLQQQVQV 2580 LSQIQSQVVA 2590 QIQAQQSGVP 2600 QQIKLQLPIQ 2610 IQQSSAVQTH 2620 QIQNVVTVQA 2630 ASVQEQLQRV 2640 QQLRDQQQKK 2650 KQQQIEIKRE 2660 HTLQASNQSE 2670 IIQKQVVMKH 2680 NAVIEHLKQK 2690 KSMTPAEREE 2700 NQRMIVCNQV 2710 MKYILDKIDK 2720 EEKQAAKKRK 2730 REESVEQKRS 2740 KQNATKLSAL 2750 LFKHKEQLRA 2760 EILKKRALLD 2770 KDLQIEVQEE 2780 LKRDLKIKKE 2790 KDLMQLAQAT 2800 AVAAPCPPVT 2810 PAPPAPPAPP 2820 PSPPPPPAVQ 2830 HTGLLSTPTL 2840 PAASQKRKRE 2850 EEKDSSSKSK 2860 KKKMISTTSK 2870 ETKKDTKLYC 2880 ICKTPYDESK 2890 FYIGCDRCQN 2900 WYHGRCVGIL 2910 QSEAELIDEY 2920 VCPQCQSTED 2930 AMTVLTPLTE 2940 KDYEGLKRVL 2950 RSLQAHKMAW 2960 PFLEPVDPND 2970 APDYYGVIKE 2980 PMDLATMEER 2990 VQRRYYEKLT 3000 EFVADMTKIF 3010 DNCRYYNPSD 3020 SPFYQCAEVL 3030 ESFFVQKLKG 3040 FKASRSHNNK LQSTAS

Gene Ontology

Classification GO ID Description
Molecular Function GO:0043565 sequence-specific DNA binding
Cellular Component GO:0044297 cell body
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030425 dendrite
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0016589 NURF complex
Cellular Component GO:0048471 perinuclear region of cytoplasm
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0007420 brain development
Biological Process GO:1990090 cellular response to nerve growth factor stimulus
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.