Search Results
Overview
| Uniprot ID | Q12834 |
|---|---|
| Protein Name | Cell division cycle protein 20 homolog |
| Gene Name | CDC20 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 149 | EGYQNRLKVLYSQKA |
| 155 | LKVLYSQKATPGSSR |
| 66 | TPGKSSSKVQTTPSK |
Function
Substrate-specific adapter and activator of the anaphase promoting complex/cyclosome (APC/C) that confers substrate specificity by binding to substrates and targeting them to the APC/C for ubiquitination and degradation (PubMed:9734353, PubMed:27030811, PubMed:29343641, PubMed:27120157, PubMed:27509861). Essential for activating APC/C in the metaphase/anaphase transition of the cell cycle, targeting the degradation of cyclin B and securin (PubMed:27120157, PubMed:27509861, PubMed:32666501). Recognizes and binds the destruction box (D box), KEB box and ABBA motifs on protein substrates (PubMed:29343641, PubMed:27509861). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity). Component of the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation until all chromosomes are properly attached to the mitotic spindle (PubMed:27509861). The MCC, which consists of CDC20, MAD2L1/MAD2, BUB1B/BUBR1 and BUB3, is a key player of the spindle assembly checkpoint (PubMed:27509861). The MCC-bound APC/C complex is inactive and this delays the metaphase/anaphase transition (PubMed:9811605, PubMed:9637688, PubMed:27509861). When the spindle assembly checkpoint is silenced, the MCC-APC/C complex recruits the E2 enzyme UBCH10 and triggers the auto-ubiquitination of CDC20 in the MCC, thereby reactivating APC/C for transition into anaphase (PubMed:27509861)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005680 | anaphase-promoting complex |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005819 | spindle |
| Cellular Component | GO:0000922 | spindle pole |
| Molecular Function | GO:0010997 | anaphase-promoting complex binding |
| Molecular Function | GO:0042826 | histone deacetylase binding |
| Molecular Function | GO:1990757 | ubiquitin ligase activator activity |
| Molecular Function | GO:1990756 | ubiquitin-like ligase-substrate adaptor activity |
| Biological Process | GO:0031145 | anaphase-promoting complex-dependent catabolic process |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0044784 | metaphase/anaphase transition of cell cycle |
| Biological Process | GO:1990949 | metaphase/anaphase transition of meiosis I |
| Biological Process | GO:0007094 | mitotic spindle assembly checkpoint signaling |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:1905786 | positive regulation of anaphase-promoting complex-dependent catabolic process |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0045842 | positive regulation of mitotic metaphase/anaphase transition |
| Biological Process | GO:0090129 | positive regulation of synapse maturation |
| Biological Process | GO:0031915 | positive regulation of synaptic plasticity |
| Biological Process | GO:1904668 | positive regulation of ubiquitin protein ligase activity |
| Biological Process | GO:0016567 | protein ubiquitination |
| Biological Process | GO:0050773 | regulation of dendrite development |
| Biological Process | GO:0051445 | regulation of meiotic cell cycle |
| Biological Process | GO:0007346 | regulation of mitotic cell cycle |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.