Search Results

Overview

Uniprot IDQ12837
Protein NamePOU domain, class 4, transcription factor 2
Gene NamePOU4F2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
124 VDIVSQSKSHHHHPP

Function

Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells (PubMed:19266028, PubMed:23805044). Functions either as activator or repressor modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner (PubMed:19266028, PubMed:23805044). Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding. Inhibits DLX1 and DLX2 transcriptional activities preventing DLX1- and DLX2-mediated ability to promote amacrine cell fate specification. In cooperation with TP53 potentiates transcriptional activation of BAX promoter activity increasing neuronal cell apoptosis. Negatively regulates BAX promoter activity in the absence of TP53. Acts as a transcriptional coactivator via its interaction with the transcription factor ESR1 by enhancing its effect on estrogen response element (ERE)-containing promoter. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to an octamer motif. Involved in TNFSF11-mediated terminal osteoclast differentiation (By similarity)

Protein Sequence

10 MMMMSLNSKQ 20 AFSMPHGGSL 30 HVEPKYSALH 40 STSPGSSAPI 50 APSASSPSSS 60 SNAGGGGGGG 70 GGGGGGGGRS 80 SSSSSSGSSG 90 GGGSEAMRRA 100 CLPTPPSNIF 110 GGLDESLLAR 120 AEALAAVDIV 130 SQSKSHHHHP 140 PHHSPFKPDA 150 TYHTMNTIPC 160 TSAASSSSVP 170 ISHPSALAGT 180 HHHHHHHHHH 190 HHQPHQALEG 200 ELLEHLSPGL 210 ALGAMAGPDG 220 AVVSTPAHAP 230 HMATMNPMHQ 240 AALSMAHAHG 250 LPSHMGCMSD 260 VDADPRDLEA 270 FAERFKQRRI 280 KLGVTQADVG 290 SALANLKIPG 300 VGSLSQSTIC 310 RFESLTLSHN 320 NMIALKPILQ 330 AWLEEAEKSH 340 REKLTKPELF 350 NGAEKKRKRT 360 SIAAPEKRSL 370 EAYFAIQPRP 380 SSEKIAAIAE 390 KLDLKKNVVR 400 VWFCNQRQKQ KRMKYSAGI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0000791 euchromatin
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005667 transcription regulator complex
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0002039 p53 binding
Molecular Function GO:1990841 promoter-specific chromatin binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Process GO:0007411 axon guidance
Biological Process GO:0071345 cellular response to cytokine stimulus
Biological Process GO:0071392 cellular response to estradiol stimulus
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:1990791 dorsal root ganglion development
Biological Process GO:0030520 estrogen receptor signaling pathway
Biological Process GO:0007507 heart development
Biological Process GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Biological Process GO:0000165 MAPK cascade
Biological Process GO:1904178 negative regulation of adipose tissue development
Biological Process GO:1902870 negative regulation of amacrine cell differentiation
Biological Process GO:0045596 negative regulation of cell differentiation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0030182 neuron differentiation
Biological Process GO:0045773 positive regulation of axon extension
Biological Process GO:0045597 positive regulation of cell differentiation
Biological Process GO:0046326 positive regulation of D-glucose import across plasma membrane
Biological Process GO:0045672 positive regulation of osteoclast differentiation
Biological Process GO:0043068 positive regulation of programmed cell death
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:2000679 positive regulation of transcription regulatory region DNA binding
Biological Process GO:0090259 regulation of retinal ganglion cell axon guidance
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0060041 retina development in camera-type eye

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.