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Overview

Uniprot IDQ12857
Protein NameNuclear factor 1 A-type
Gene NameNFIA
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
276 TSSTSSTKRLKSVED

Function

Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication

Protein Sequence

10 MYSPLCLTQD 20 EFHPFIEALL 30 PHVRAFAYTW 40 FNLQARKRKY 50 FKKHEKRMSK 60 EEERAVKDEL 70 LSEKPEVKQK 80 WASRLLAKLR 90 KDIRPEYRED 100 FVLTVTGKKP 110 PCCVLSNPDQ 120 KGKMRRIDCL 130 RQADKVWRLD 140 LVMVILFKGI 150 PLESTDGERL 160 VKSPQCSNPG 170 LCVQPHHIGV 180 SVKELDLYLA 190 YFVHAADSSQ 200 SESPSQPSDA 210 DIKDQPENGH 220 LGFQDSFVTS 230 GVFSVTELVR 240 VSQTPIAAGT 250 GPNFSLSDLE 260 SSSYYSMSPG 270 AMRRSLPSTS 280 STSSTKRLKS 290 VEDEMDSPGE 300 EPFYTGQGRS 310 PGSGSQSSGW 320 HEVEPGMPSP 330 TTLKKSEKSG 340 FSSPSPSQTS 350 SLGTAFTQHH 360 RPVITGPRAS 370 PHATPSTLHF 380 PTSPIIQQPG 390 PYFSHPAIRY 400 HPQETLKEFV 410 QLVCPDAGQQ 420 AGQVGFLNPN 430 GSSQGKVHNP 440 FLPTPMLPPP 450 PPPPMARPVP 460 LPVPDTKPPT 470 TSTEGGAASP 480 TSPTYSTPST 490 SPANRFVSVG 500 PRDPSFVNIP QQTQSWYLG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0140297 DNA-binding transcription factor binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Process GO:0030509 BMP signaling pathway
Biological Process GO:0051216 cartilage development
Biological Process GO:0000902 cell morphogenesis
Biological Process GO:0006260 DNA replication
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0035108 limb morphogenesis
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0019079 viral genome replication

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.