Search Results

Overview

Uniprot IDQ12860
Protein NameContactin-1
Gene NameCNTN1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
238 PIPERTTKPYPADIV
428 KKKILAAKGGRVIIE
756 FDGEEWKKVTVTNPD
850 RYWAAHDKEEAANRV

Function

Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity)

Protein Sequence

10 MKMWLLVSHL 20 VIISITTCLA 30 EFTWYRRYGH 40 GVSEEDKGFG 50 PIFEEQPINT 60 IYPEESLEGK 70 VSLNCRARAS 80 PFPVYKWRMN 90 NGDVDLTSDR 100 YSMVGGNLVI 110 NNPDKQKDAG 120 IYYCLASNNY 130 GMVRSTEATL 140 SFGYLDPFPP 150 EERPEVRVKE 160 GKGMVLLCDP 170 PYHFPDDLSY 180 RWLLNEFPVF 190 ITMDKRRFVS 200 QTNGNLYIAN 210 VEASDKGNYS 220 CFVSSPSITK 230 SVFSKFIPLI 240 PIPERTTKPY 250 PADIVVQFKD 260 VYALMGQNVT 270 LECFALGNPV 280 PDIRWRKVLE 290 PMPSTAEIST 300 SGAVLKIFNI 310 QLEDEGIYEC 320 EAENIRGKDK 330 HQARIYVQAF 340 PEWVEHINDT 350 EVDIGSDLYW 360 PCVATGKPIP 370 TIRWLKNGYA 380 YHKGELRLYD 390 VTFENAGMYQ 400 CIAENTYGAI 410 YANAELKILA 420 LAPTFEMNPM 430 KKKILAAKGG 440 RVIIECKPKA 450 APKPKFSWSK 460 GTEWLVNSSR 470 ILIWEDGSLE 480 INNITRNDGG 490 IYTCFAENNR 500 GKANSTGTLV 510 ITDPTRIILA 520 PINADITVGE 530 NATMQCAASF 540 DPALDLTFVW 550 SFNGYVIDFN 560 KENIHYQRNF 570 MLDSNGELLI 580 RNAQLKHAGR 590 YTCTAQTIVD 600 NSSASADLVV 610 RGPPGPPGGL 620 RIEDIRATSV 630 ALTWSRGSDN 640 HSPISKYTIQ 650 TKTILSDDWK 660 DAKTDPPIIE 670 GNMEAARAVD 680 LIPWMEYEFR 690 VVATNTLGRG 700 EPSIPSNRIK 710 TDGAAPNVAP 720 SDVGGGGGRN 730 RELTITWAPL 740 SREYHYGNNF 750 GYIVAFKPFD 760 GEEWKKVTVT 770 NPDTGRYVHK 780 DETMSPSTAF 790 QVKVKAFNNK 800 GDGPYSLVAV 810 INSAQDAPSE 820 APTEVGVKVL 830 SSSEISVHWE 840 HVLEKIVESY 850 QIRYWAAHDK 860 EEAANRVQVT 870 SQEYSARLEN 880 LLPDTQYFIE 890 VGACNSAGCG 900 PPSDMIEAFT 910 KKAPPSQPPR 920 IISSVRSGSR 930 YIITWDHVVA 940 LSNESTVTGY 950 KVLYRPDGQH 960 DGKLYSTHKH 970 SIEVPIPRDG 980 EYVVEVRAHS 990 DGGDGVVSQV 1000 KISGAPTLSP 1010 SLLGLLLPAF GILVYLEF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0016020 membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0045211 postsynaptic membrane
Cellular Component GO:0042734 presynaptic membrane
Cellular Component GO:0098552 side of membrane
Molecular Function GO:0030246 carbohydrate binding
Molecular Function GO:0098632 cell-cell adhesion mediator activity
Biological Process GO:0007411 axon guidance
Biological Process GO:0007420 brain development
Biological Process GO:0007155 cell adhesion
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0032289 central nervous system myelin formation
Biological Process GO:0007626 locomotory behavior
Biological Process GO:0007219 Notch signaling pathway

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.