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Overview

Uniprot IDQ12872
Protein NameSplicing factor, suppressor of white-apricot homolog
Gene NameSFSWAP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
564 KKEASSSKTVPDGKL
666 LAAAAREKLAQASKE
686 LQAERKRKAALFLQT
927 IVSSVQSKITQDLMA

Function

Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10

Protein Sequence

10 MYGASGGRAK 20 PERKSGAKEE 30 AGPGGAGGGG 40 SRVELLVFGY 50 ACKLFRDDER 60 ALAQEQGQHL 70 IPWMGDHKIL 80 IDRYDGRGHL 90 HDLSEYDAEY 100 STWNRDYQLS 110 EEEARIEALC 120 DEERYLALHT 130 DLLEEEARQE 140 EEYKRLSEAL 150 AEDGSYNAVG 160 FTYGSDYYDP 170 SEPTEEEEPS 180 KQREKNEAEN 190 LEENEEPFVA 200 PLGLSVPSDV 210 ELPPTAKMHA 220 IIERTASFVC 230 RQGAQFEIML 240 KAKQARNSQF 250 DFLRFDHYLN 260 PYYKFIQKAM 270 KEGRYTVLAE 280 NKSDEKKKSG 290 VSSDNEDDDD 300 EEDGNYLHPS 310 LFASKKCNRL 320 EELMKPLKVV 330 DPDHPLAALV 340 RKAQADSSTP 350 TPHNADGAPV 360 QPSQVEYTAD 370 STVAAMYYSY 380 YMLPDGTYCL 390 APPPPGIDVT 400 TYYSTLPAGV 410 TVSNSPGVTT 420 TAPPPPGTTP 430 LPPPTTAETS 440 SGATSTTTTT 450 SALAPVAAII 460 PPPPDVQPVI 470 DKLAEYVARN 480 GLKFETSVRA 490 KNDQRFEFLQ 500 PWHQYNAYYE 510 FKKQFFLQKE 520 GGDSMQAVSA 530 PEEAPTDSAP 540 EKPSDAGEDG 550 APEDAAEVGA 560 RAGSGGKKEA 570 SSSKTVPDGK 580 LVKASFAPIS 590 FAIKAKENDL 600 LPLEKNRVKL 610 DDDSDDDEES 620 KEGQESSSSA 630 ANTNPAVAPP 640 CVVVEEKKPQ 650 LTQEELEAKQ 660 AKQKLEDRLA 670 AAAREKLAQA 680 SKESKEKQLQ 690 AERKRKAALF 700 LQTLKNPLPE 710 AEAGKIEESP 720 FSVEESSTTP 730 CPLLTGGRPL 740 PTLEVKPPDR 750 PSSKSKDPPR 760 EEEKEKKKKK 770 HKKRSRTRSR 780 SPKYHSSSKS 790 RSRSHSKAKH 800 SLPSAYRTVR 810 RSRSRSRSPR 820 RRAHSPERRR 830 EERSVPTAYR 840 VSRSPGASRK 850 RTRSRSPHEK 860 KKKRRSRSRT 870 KSKARSQSVS 880 PSKQAAPRPA 890 APAAHSAHSA 900 SVSPVESRGS 910 SQERSRGVSQ 920 EKEAQISSAI 930 VSSVQSKITQ 940 DLMAKVRAML 950 AASKNLQTSA S

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0000395 mRNA 5'-splice site recognition
Biological Process GO:0048025 negative regulation of mRNA splicing, via spliceosome

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.