Search Results

Overview

Uniprot IDQ12873
Protein NameATP-dependent chromatin remodeler CHD3
Gene NameCHD3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
295 KMAPLKIKLGLLGGK
302 KLGLLGGKRKKGGSY
48 LPSALGVKKRKRGPK
644 INHSVDKKGNYHYLV

Function

ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666, PubMed:30397230, PubMed:9804427). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165)

Protein Sequence

10 MKAADTVILW 20 ARSKNDQLRI 30 SFPPGLCWGD 40 RMPDKDDIRL 50 LPSALGVKKR 60 KRGPKKQKEN 70 KPGKPRKRKK 80 RDSEEEFGSE 90 RDEYREKSES 100 GGSEYGTGPG 110 RKRRRKHREK 120 KEKKTKRRKK 130 GEGDGGQKQV 140 EQKSSATLLL 150 TWGLEDVEHV 160 FSEEDYHTLT 170 NYKAFSQFMR 180 PLIAKKNPKI 190 PMSKMMTILG 200 AKWREFSANN 210 PFKGSAAAVA 220 AAAAAAAAAV 230 AEQVSAAVSS 240 ATPIAPSGPP 250 ALPPPPAADI 260 QPPPIRRAKT 270 KEGKGPGHKR 280 RSKSPRVPDG 290 RKKLRGKKMA 300 PLKIKLGLLG 310 GKRKKGGSYV 320 FQSDEGPEPE 330 AEESDLDSGS 340 VHSASGRPDG 350 PVRTKKLKRG 360 RPGRKKKKVL 370 GCPAVAGEEE 380 VDGYETDHQD 390 YCEVCQQGGE 400 IILCDTCPRA 410 YHLVCLDPEL 420 DRAPEGKWSC 430 PHCEKEGVQW 440 EAKEEEEEYE 450 EEGEEEGEKE 460 EEDDHMEYCR 470 VCKDGGELLC 480 CDACISSYHI 490 HCLNPPLPDI 500 PNGEWLCPRC 510 TCPVLKGRVQ 520 KILHWRWGEP 530 PVAVPAPQQA 540 DGNPDVPPPR 550 PLQGRSEREF 560 FVKWVGLSYW 570 HCSWAKELQL 580 EIFHLVMYRN 590 YQRKNDMDEP 600 PPLDYGSGED 610 DGKSDKRKVK 620 DPHYAEMEEK 630 YYRFGIKPEW 640 MTVHRIINHS 650 VDKKGNYHYL 660 VKWRDLPYDQ 670 STWEEDEMNI 680 PEYEEHKQSY 690 WRHRELIMGE 700 DPAQPRKYKK 710 KKKELQGDGP 720 PSSPTNDPTV 730 KYETQPRFIT 740 ATGGTLHMYQ 750 LEGLNWLRFS 760 WAQGTDTILA 770 DEMGLGKTIQ 780 TIVFLYSLYK 790 EGHTKGPFLV 800 SAPLSTIINW 810 EREFQMWAPK 820 FYVVTYTGDK 830 DSRAIIRENE 840 FSFEDNAIKG 850 GKKAFKMKRE 860 AQVKFHVLLT 870 SYELITIDQA 880 ALGSIRWACL 890 VVDEAHRLKN 900 NQSKFFRVLN 910 GYKIDHKLLL 920 TGTPLQNNLE 930 ELFHLLNFLT 940 PERFNNLEGF 950 LEEFADISKE 960 DQIKKLHDLL 970 GPHMLRRLKA 980 DVFKNMPAKT 990 ELIVRVELSP 1000 MQKKYYKYIL 1010 TRNFEALNSR 1020 GGGNQVSLLN 1030 IMMDLKKCCN 1040 HPYLFPVAAM 1050 ESPKLPSGAY 1060 EGGALIKSSG 1070 KLMLLQKMLR 1080 KLKEQGHRVL 1090 IFSQMTKMLD 1100 LLEDFLDYEG 1110 YKYERIDGGI 1120 TGALRQEAID 1130 RFNAPGAQQF 1140 CFLLSTRAGG 1150 LGINLATADT 1160 VIIFDSDWNP 1170 HNDIQAFSRA 1180 HRIGQANKVM 1190 IYRFVTRASV 1200 EERITQVAKR 1210 KMMLTHLVVR 1220 PGLGSKAGSM 1230 SKQELDDILK 1240 FGTEELFKDE 1250 NEGENKEEDS 1260 SVIHYDNEAI 1270 ARLLDRNQDA 1280 TEDTDVQNMN 1290 EYLSSFKVAQ 1300 YVVREEDKIE 1310 EIEREIIKQE 1320 ENVDPDYWEK 1330 LLRHHYEQQQ 1340 EDLARNLGKG 1350 KRVRKQVNYN 1360 DAAQEDQDNQ 1370 SEYSVGSEEE 1380 DEDFDERPEG 1390 RRQSKRQLRN 1400 EKDKPLPPLL 1410 ARVGGNIEVL 1420 GFNTRQRKAF 1430 LNAVMRWGMP 1440 PQDAFTTQWL 1450 VRDLRGKTEK 1460 EFKAYVSLFM 1470 RHLCEPGADG 1480 SETFADGVPR 1490 EGLSRQQVLT 1500 RIGVMSLVKK 1510 KVQEFEHING 1520 RWSMPELMPD 1530 PSADSKRSSR 1540 ASSPTKTSPT 1550 TPEASATNSP 1560 CTSKPATPAP 1570 SEKGEGIRTP 1580 LEKEEAENQE 1590 EKPEKNSRIG 1600 EKMETEADAP 1610 SPAPSLGERL 1620 EPRKIPLEDE 1630 VPGVPGEMEP 1640 EPGYRGDREK 1650 SATESTPGER 1660 GEEKPLDGQE 1670 HRERPEGETG 1680 DLGKREDVKG 1690 DRELRPGPRD 1700 EPRSNGRREE 1710 KTEKPRFMFN 1720 IADGGFTELH 1730 TLWQNEERAA 1740 ISSGKLNEIW 1750 HRRHDYWLLA 1760 GIVLHGYARW 1770 QDIQNDAQFA 1780 IINEPFKTEA 1790 NKGNFLEMKN 1800 KFLARRFKLL 1810 EQALVIEEQL 1820 RRAAYLNLSQ 1830 EPAHPAMALH 1840 ARFAEAECLA 1850 ESHQHLSKES 1860 LAGNKPANAV 1870 LHKVLNQLEE 1880 LLSDMKADVT 1890 RLPATLSRIP 1900 PIAARLQMSE 1910 RSILSRLASK 1920 GTEPHPTPAY 1930 PPGPYATPPG 1940 YGAAFSAAPV 1950 GALAAAGANY 1960 SQMPAGSFIT 1970 AATNGPPVLV 1980 KKEKEMVGAL 1990 VSDGLDRKEP 2000 RAGEVICIDD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0016581 NuRD complex
Cellular Component GO:0016605 PML body
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0140658 ATP-dependent chromatin remodeler activity
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0004386 helicase activity
Molecular Function GO:0042393 histone binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0000976 transcription cis-regulatory region binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0007098 centrosome cycle
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0042659 regulation of cell fate specification
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:2000736 regulation of stem cell differentiation
Biological Process GO:0007051 spindle organization

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.