Search Results

Overview

Uniprot IDQ12882
Protein NameDihydropyrimidine dehydrogenase [NADP(+)]
Gene NameDPYD
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1014 RTTPYEPKRGVPLSV
898 AENKIRLKEQNVAFS

Function

Involved in pyrimidine base degradation (PubMed:1512248). Catalyzes the reduction of uracil and thymine (PubMed:1512248). Also involved the degradation of the chemotherapeutic drug 5-fluorouracil (PubMed:1512248)

Protein Sequence

10 MAPVLSKDSA 20 DIESILALNP 30 RTQTHATLCS 40 TSAKKLDKKH 50 WKRNPDKNCF 60 NCEKLENNFD 70 DIKHTTLGER 80 GALREAMRCL 90 KCADAPCQKS 100 CPTNLDIKSF 110 ITSIANKNYY 120 GAAKMIFSDN 130 PLGLTCGMVC 140 PTSDLCVGGC 150 NLYATEEGPI 160 NIGGLQQFAT 170 EVFKAMSIPQ 180 IRNPSLPPPE 190 KMSEAYSAKI 200 ALFGAGPASI 210 SCASFLARLG 220 YSDITIFEKQ 230 EYVGGLSTSE 240 IPQFRLPYDV 250 VNFEIELMKD 260 LGVKIICGKS 270 LSVNEMTLST 280 LKEKGYKAAF 290 IGIGLPEPNK 300 DAIFQGLTQD 310 QGFYTSKDFL 320 PLVAKGSKAG 330 MCACHSPLPS 340 IRGVVIVLGA 350 GDTAFDCATS 360 ALRCGARRVF 370 IVFRKGFVNI 380 RAVPEEMELA 390 KEEKCEFLPF 400 LSPRKVIVKG 410 GRIVAMQFVR 420 TEQDETGKWN 430 EDEDQMVHLK 440 ADVVISAFGS 450 VLSDPKVKEA 460 LSPIKFNRWG 470 LPEVDPETMQ 480 TSEAWVFAGG 490 DVVGLANTTV 500 ESVNDGKQAS 510 WYIHKYVQSQ 520 YGASVSAKPE 530 LPLFYTPIDL 540 VDISVEMAGL 550 KFINPFGLAS 560 ATPATSTSMI 570 RRAFEAGWGF 580 ALTKTFSLDK 590 DIVTNVSPRI 600 IRGTTSGPMY 610 GPGQSSFLNI 620 ELISEKTAAY 630 WCQSVTELKA 640 DFPDNIVIAS 650 IMCSYNKNDW 660 TELAKKSEDS 670 GADALELNLS 680 CPHGMGERGM 690 GLACGQDPEL 700 VRNICRWVRQ 710 AVQIPFFAKL 720 TPNVTDIVSI 730 ARAAKEGGAN 740 GVTATNTVSG 750 LMGLKSDGTP 760 WPAVGIAKRT 770 TYGGVSGTAI 780 RPIALRAVTS 790 IARALPGFPI 800 LATGGIDSAE 810 SGLQFLHSGA 820 SVLQVCSAIQ 830 NQDFTVIEDY 840 CTGLKALLYL 850 KSIEELQDWD 860 GQSPATVSHQ 870 KGKPVPRIAE 880 LMDKKLPSFG 890 PYLEQRKKII 900 AENKIRLKEQ 910 NVAFSPLKRN 920 CFIPKRPIPT 930 IKDVIGKALQ 940 YLGTFGELSN 950 VEQVVAMIDE 960 EMCINCGKCY 970 MTCNDSGYQA 980 IQFDPETHLP 990 TITDTCTGCT 1000 LCLSVCPIVD 1010 CIKMVSRTTP 1020 YEPKRGVPLS VNPVC

Gene Ontology

Classification GO ID Description
Molecular Function GO:0050661 NADP binding
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Molecular Function GO:0051539 4 iron, 4 sulfur cluster binding
Molecular Function GO:0017113 dihydropyrimidine dehydrogenase (NADP+) activity
Molecular Function GO:0050660 flavin adenine dinucleotide binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0002058 uracil binding
Biological Process GO:0019483 beta-alanine biosynthetic process
Biological Process GO:0006248 CMP catabolic process
Biological Process GO:0006249 dCMP catabolic process
Biological Process GO:0046079 dUMP catabolic process
Biological Process GO:0006145 purine nucleobase catabolic process
Biological Process GO:0006208 pyrimidine nucleobase catabolic process
Biological Process GO:0006214 thymidine catabolic process
Biological Process GO:0006210 thymine catabolic process
Biological Process GO:0046045 TMP catabolic process
Biological Process GO:0046050 UMP catabolic process
Biological Process GO:0006212 uracil catabolic process
Biological Process GO:0042178 xenobiotic catabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.