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Overview

Uniprot ID	Q12905
Protein Name	Interleukin enhancer-binding factor 2
Gene Name	ILF2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
186	TVPPNLRKLDPELHL
45	EMAFPRVKPAPDETS

Function

Chromatin-interacting protein that forms a stable heterodimer with interleukin enhancer-binding factor 3/ILF3 and plays a role in several biological processes including transcription, innate immunity or cell growth (PubMed:18458058, PubMed:31212927). Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. Together with ILF3, forms an RNA-binding complex that is required for mitotic progression and cytokinesis by regulating the expression of a cluster of mitotic genes. Mechanistically, competes with STAU1/STAU2-mediated mRNA decay (PubMed:32433969). Also plays a role in the inhibition of various viruses including Japanese encephalitis virus or enterovirus 71

Protein Sequence

10 MRGDRGRGRG 20 GRFGSRGGPG 30 GGFRPFVPHI 40 PFDFYLCEMA 50 FPRVKPAPDE 60 TSFSEALLKR 70 NQDLAPNSAE 80 QASILSLVTK 90 INNVIDNLIV 100 APGTFEVQIE 110 EVRQVGSYKK 120 GTMTTGHNVA 130 DLVVILKILP 140 TLEAVAALGN 150 KVVESLRAQD 160 PSEVLTMLTN 170 ETGFEISSSD 180 ATVKILITTV 190 PPNLRKLDPE 200 LHLDIKVLQS 210 ALAAIRHARW 220 FEENASQSTV 230 KVLIRLLKDL 240 RIRFPGFEPL 250 TPWILDLLGH 260 YAVMNNPTRQ 270 PLALNVAYRR 280 CLQILAAGLF 290 LPGSVGITDP 300 CESGNFRVHT 310 VMTLEQQDMV 320 CYTAQTLVRI 330 LSHGGFRKIL 340 GQEGDASYLA 350 SEISTWDGVI 360 VTPSEKAYEK 370 PPEKKEGEEE 380 EENTEEPPQG 390 EEEESMETQE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:1904813	ficolin-1-rich granule lumen
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:1990904	ribonucleoprotein complex
Cellular Component	GO:0035580	specific granule lumen
Cellular Component	GO:1904724	tertiary granule lumen
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0003725	double-stranded RNA binding
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0045893	positive regulation of DNA-templated transcription

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.