Search Results
Overview
| Uniprot ID | Q12907 |
|---|---|
| Protein Name | Vesicular integral-membrane protein VIP36 |
| Gene Name | LMAN2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 303 | VNFLKSPKDNVDDPT |
Function
Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity)
Protein Sequence
10
MAAEGWIWRW
20
GWGRRCLGRP
30
GLLGPGPGPT
40
TPLFLLLLLG
50
SVTADITDGN
60
SEHLKREHSL
70
IKPYQGVGSS
80
SMPLWDFQGS
90
TMLTSQYVRL
100
TPDERSKEGS
110
IWNHQPCFLK
120
DWEMHVHFKV
130
HGTGKKNLHG
140
DGIALWYTRD
150
RLVPGPVFGS
160
KDNFHGLAIF
170
LDTYPNDETT
180
ERVFPYISVM
190
VNNGSLSYDH
200
SKDGRWTELA
210
GCTADFRNRD
220
HDTFLAVRYS
230
RGRLTVMTDL
240
EDKNEWKNCI
250
DITGVRLPTG
260
YYFGASAGTG
270
DLSDNHDIIS
280
MKLFQLMVEH
290
TPDEESIDWT
300
KIEPSVNFLK
310
SPKDNVDDPT
320
GNFRSGPLTG
330
WRVFLLLLCA
340
LLGIVVCAVV
350
GAVVFQKRQE
RNKRFY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0030134 | COPII-coated ER to Golgi transport vesicle |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| Cellular Component | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0030246 | carbohydrate binding |
| Molecular Function | GO:0005537 | D-mannose binding |
| Molecular Function | GO:0031072 | heat shock protein binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Biological Process | GO:0050766 | positive regulation of phagocytosis |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.