Overview
| Uniprot ID | Q12913 |
|---|
| Protein Name | Receptor-type tyrosine-protein phosphatase eta |
|---|
| Gene Name | PTPRJ |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 1014 |
EVSFSQIKPKKSKLI |
Function
Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2 (PubMed:10821867, PubMed:12062403, PubMed:12370829, PubMed:12475979, PubMed:18348712, PubMed:19494114, PubMed:19922411, PubMed:21262971). Plays a role in cell adhesion, migration, proliferation and differentiation (PubMed:12370829, PubMed:14709717, PubMed:16682945, PubMed:19836242). Has a role in megakaryocytes and platelet formation (PubMed:30591527). Involved in vascular development (By similarity). Regulator of macrophage adhesion and spreading (By similarity). Positively affects cell-matrix adhesion (By similarity). Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation (PubMed:16682945). Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR (PubMed:21091576). Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation (PubMed:18936167). Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation (PubMed:19836242). Enhances the barrier function of epithelial junctions during reassembly (PubMed:19332538). Negatively regulates T-cell receptor (TCR) signaling (PubMed:11259588, PubMed:9531590, PubMed:9780142). Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling (PubMed:11259588, PubMed:12913111)
Protein Sequence
10
MKPAAREARL
20
PPRSPGLRWA
30
LPLLLLLLRL
40
GQILCAGGTP
50
SPIPDPSVAT
60
VATGENGITQ
70
ISSTAESFHK
80
QNGTGTPQVE
90
TNTSEDGESS
100
GANDSLRTPE
110
QGSNGTDGAS
120
QKTPSSTGPS
130
PVFDIKAVSI
140
SPTNVILTWK
150
SNDTAASEYK
160
YVVKHKMENE
170
KTITVVHQPW
180
CNITGLRPAT
190
SYVFSITPGI
200
GNETWGDPRV
210
IKVITEPIPV
220
SDLRVALTGV
230
RKAALSWSNG
240
NGTASCRVLL
250
ESIGSHEELT
260
QDSRLQVNIS
270
GLKPGVQYNI
280
NPYLLQSNKT
290
KGDPLGTEGG
300
LDASNTERSR
310
AGSPTAPVHD
320
ESLVGPVDPS
330
SGQQSRDTEV
340
LLVGLEPGTR
350
YNATVYSQAA
360
NGTEGQPQAI
370
EFRTNAIQVF
380
DVTAVNISAT
390
SLTLIWKVSD
400
NESSSNYTYK
410
IHVAGETDSS
420
NLNVSEPRAV
430
IPGLRSSTFY
440
NITVCPVLGD
450
IEGTPGFLQV
460
HTPPVPVSDF
470
RVTVVSTTEI
480
GLAWSSHDAE
490
SFQMHITQEG
500
AGNSRVEITT
510
NQSIIIGGLF
520
PGTKYCFEIV
530
PKGPNGTEGA
540
SRTVCNRTVP
550
SAVFDIHVVY
560
VTTTEMWLDW
570
KSPDGASEYV
580
YHLVIESKHG
590
SNHTSTYDKA
600
ITLQGLIPGT
610
LYNITISPEV
620
DHVWGDPNST
630
AQYTRPSNVS
640
NIDVSTNTTA
650
ATLSWQNFDD
660
ASPTYSYCLL
670
IEKAGNSSNA
680
TQVVTDIGIT
690
DATVTELIPG
700
SSYTVEIFAQ
710
VGDGIKSLEP
720
GRKSFCTDPA
730
SMASFDCEVV
740
PKEPALVLKW
750
TCPPGANAGF
760
ELEVSSGAWN
770
NATHLESCSS
780
ENGTEYRTEV
790
TYLNFSTSYN
800
ISITTVSCGK
810
MAAPTRNTCT
820
TGITDPPPPD
830
GSPNITSVSH
840
NSVKVKFSGF
850
EASHGPIKAY
860
AVILTTGEAG
870
HPSADVLKYT
880
YEDFKKGASD
890
TYVTYLIRTE
900
EKGRSQSLSE
910
VLKYEIDVGN
920
ESTTLGYYNG
930
KLEPLGSYRA
940
CVAGFTNITF
950
HPQNKGLIDG
960
AESYVSFSRY
970
SDAVSLPQDP
980
GVICGAVFGC
990
IFGALVIVTV
1000
GGFIFWRKKR
1010
KDAKNNEVSF
1020
SQIKPKKSKL
1030
IRVENFEAYF
1040
KKQQADSNCG
1050
FAEEYEDLKL
1060
VGISQPKYAA
1070
ELAENRGKNR
1080
YNNVLPYDIS
1090
RVKLSVQTHS
1100
TDDYINANYM
1110
PGYHSKKDFI
1120
ATQGPLPNTL
1130
KDFWRMVWEK
1140
NVYAIIMLTK
1150
CVEQGRTKCE
1160
EYWPSKQAQD
1170
YGDITVAMTS
1180
EIVLPEWTIR
1190
DFTVKNIQTS
1200
ESHPLRQFHF
1210
TSWPDHGVPD
1220
TTDLLINFRY
1230
LVRDYMKQSP
1240
PESPILVHCS
1250
AGVGRTGTFI
1260
AIDRLIYQIE
1270
NENTVDVYGI
1280
VYDLRMHRPL
1290
MVQTEDQYVF
1300
LNQCVLDIVR
1310
SQKDSKVDLI
1320
YQNTTAMTIY
1330
ENLAPVTTFG
KTNGYIA
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:0060369 |
positive regulation of Fc receptor mediated stimulatory signaling pathway |
| Cellular Component |
GO:0030054 |
cell junction |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0005911 |
cell-cell junction |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0001772 |
immunological synapse |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0032587 |
ruffle membrane |
| Cellular Component |
GO:0035579 |
specific granule membrane |
| Molecular Function |
GO:0008013 |
beta-catenin binding |
| Molecular Function |
GO:0045296 |
cadherin binding |
| Molecular Function |
GO:0070097 |
delta-catenin binding |
| Molecular Function |
GO:0045295 |
gamma-catenin binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0051019 |
mitogen-activated protein kinase binding |
| Molecular Function |
GO:0016791 |
phosphatase activity |
| Molecular Function |
GO:0005161 |
platelet-derived growth factor receptor binding |
| Molecular Function |
GO:0019901 |
protein kinase binding |
| Molecular Function |
GO:0004725 |
protein tyrosine phosphatase activity |
| Biological Process |
GO:0001525 |
angiogenesis |
| Biological Process |
GO:0007411 |
axon guidance |
| Biological Process |
GO:0030183 |
B cell differentiation |
| Biological Process |
GO:0007596 |
blood coagulation |
| Biological Process |
GO:0060242 |
contact inhibition |
| Biological Process |
GO:0019221 |
cytokine-mediated signaling pathway |
| Biological Process |
GO:0042593 |
glucose homeostasis |
| Biological Process |
GO:0030308 |
negative regulation of cell growth |
| Biological Process |
GO:0030336 |
negative regulation of cell migration |
| Biological Process |
GO:0008285 |
negative regulation of cell population proliferation |
| Biological Process |
GO:0042059 |
negative regulation of epidermal growth factor receptor signaling pathway |
| Biological Process |
GO:0046627 |
negative regulation of insulin receptor signaling pathway |
| Biological Process |
GO:0043407 |
negative regulation of MAP kinase activity |
| Biological Process |
GO:0051898 |
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process |
GO:0010642 |
negative regulation of platelet-derived growth factor receptor signaling pathway |
| Biological Process |
GO:0050860 |
negative regulation of T cell receptor signaling pathway |
| Biological Process |
GO:0043116 |
negative regulation of vascular permeability |
| Biological Process |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
| Biological Process |
GO:0030220 |
platelet formation |
| Biological Process |
GO:0048008 |
platelet-derived growth factor receptor signaling pathway |
| Biological Process |
GO:0050918 |
positive chemotaxis |
| Biological Process |
GO:0050850 |
positive regulation of calcium-mediated signaling |
| Biological Process |
GO:0045785 |
positive regulation of cell adhesion |
| Biological Process |
GO:0051894 |
positive regulation of focal adhesion assembly |
| Biological Process |
GO:0010759 |
positive regulation of macrophage chemotaxis |
| Biological Process |
GO:0043410 |
positive regulation of MAPK cascade |
| Biological Process |
GO:0050766 |
positive regulation of phagocytosis |
| Biological Process |
GO:0051897 |
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process |
GO:0010572 |
positive regulation of platelet activation |
| Biological Process |
GO:0032760 |
positive regulation of tumor necrosis factor production |
| Biological Process |
GO:0030155 |
regulation of cell adhesion |
| Biological Process |
GO:0007165 |
signal transduction |
| Biological Process |
GO:0050852 |
T cell receptor signaling pathway |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.