Search Results

Overview

Uniprot IDQ12931
Protein NameHeat shock protein 75 kDa, mitochondrial
Gene NameTRAP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
109 ARSLYSEKEVFIREL
126 NASDALEKLRHKLVS
324 YVAQAHDKPRYTLHY
369 SVALYSRKVLIQTKA
375 RKVLIQTKATDILPK
431 KFFIDQSKKDAEKYA
546 LREFDKKKLISVETD
598 GSRVTNVKVTLRLDT
629 LRMQQLAKTQEERAQ
95 HEFQAETKKLLDIVA
96 EFQAETKKLLDIVAR

Function

Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA

Protein Sequence

10 MARELRALLL 20 WGRRLRPLLR 30 APALAAVPGG 40 KPILCPRRTT 50 AQLGPRRNPA 60 WSLQAGRLFS 70 TQTAEDKEEP 80 LHSIISSTES 90 VQGSTSKHEF 100 QAETKKLLDI 110 VARSLYSEKE 120 VFIRELISNA 130 SDALEKLRHK 140 LVSDGQALPE 150 MEIHLQTNAE 160 KGTITIQDTG 170 IGMTQEELVS 180 NLGTIARSGS 190 KAFLDALQNQ 200 AEASSKIIGQ 210 FGVGFYSAFM 220 VADRVEVYSR 230 SAAPGSLGYQ 240 WLSDGSGVFE 250 IAEASGVRTG 260 TKIIIHLKSD 270 CKEFSSEARV 280 RDVVTKYSNF 290 VSFPLYLNGR 300 RMNTLQAIWM 310 MDPKDVREWQ 320 HEEFYRYVAQ 330 AHDKPRYTLH 340 YKTDAPLNIR 350 SIFYVPDMKP 360 SMFDVSRELG 370 SSVALYSRKV 380 LIQTKATDIL 390 PKWLRFIRGV 400 VDSEDIPLNL 410 SRELLQESAL 420 IRKLRDVLQQ 430 RLIKFFIDQS 440 KKDAEKYAKF 450 FEDYGLFMRE 460 GIVTATEQEV 470 KEDIAKLLRY 480 ESSALPSGQL 490 TSLSEYASRM 500 RAGTRNIYYL 510 CAPNRHLAEH 520 SPYYEAMKKK 530 DTEVLFCFEQ 540 FDELTLLHLR 550 EFDKKKLISV 560 ETDIVVDHYK 570 EEKFEDRSPA 580 AECLSEKETE 590 ELMAWMRNVL 600 GSRVTNVKVT 610 LRLDTHPAMV 620 TVLEMGAARH 630 FLRMQQLAKT 640 QEERAQLLQP 650 TLEINPRHAL 660 IKKLNQLRAS 670 EPGLAQLLVD 680 QIYENAMIAA 690 GLVDDPRAMV 700 GRLNELLVKA LERH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016020 membrane
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005758 mitochondrial intermembrane space
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0140662 ATP-dependent protein folding chaperone
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0005164 tumor necrosis factor receptor binding
Molecular Function GO:0051082 unfolded protein binding
Biological Process GO:1901856 negative regulation of cellular respiration
Biological Process GO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
Biological Process GO:1903427 negative regulation of reactive oxygen species biosynthetic process
Biological Process GO:0006457 protein folding
Biological Process GO:0009386 translational attenuation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.