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Overview

Uniprot IDQ12948
Protein NameForkhead box protein C1
Gene NameFOXC1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
552 AFVYDCSKF******

Function

DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:15299087, PubMed:15684392, PubMed:16449236, PubMed:16492674, PubMed:17210863, PubMed:19279310, PubMed:19793056, PubMed:25786029, PubMed:27804176, PubMed:27907090). Acts either as a transcriptional activator or repressor (PubMed:11782474). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176, PubMed:7957066). Upon DNA-binding, promotes DNA bending (PubMed:14506133, PubMed:7957066). Acts as a transcriptional coactivator (PubMed:26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity). Also acts as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PubMed:26565916). Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed:17993506). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (By similarity). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PubMed:12408963). Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PubMed:20406990, PubMed:22991501). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PubMed:27907090). Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). May function as a tumor suppressor (PubMed:12408963)

Protein Sequence

10 MQARYSVSSP 20 NSLGVVPYLG 30 GEQSYYRAAA 40 AAAGGGYTAM 50 PAPMSVYSHP 60 AHAEQYPGGM 70 ARAYGPYTPQ 80 PQPKDMVKPP 90 YSYIALITMA 100 IQNAPDKKIT 110 LNGIYQFIMD 120 RFPFYRDNKQ 130 GWQNSIRHNL 140 SLNECFVKVP 150 RDDKKPGKGS 160 YWTLDPDSYN 170 MFENGSFLRR 180 RRRFKKKDAV 190 KDKEEKDRLH 200 LKEPPPPGRQ 210 PPPAPPEQAD 220 GNAPGPQPPP 230 VRIQDIKTEN 240 GTCPSPPQPL 250 SPAAALGSGS 260 AAAVPKIESP 270 DSSSSSLSSG 280 SSPPGSLPSA 290 RPLSLDGADS 300 APPPPAPSAP 310 PPHHSQGFSV 320 DNIMTSLRGS 330 PQSAAAELSS 340 GLLASAAASS 350 RAGIAPPLAL 360 GAYSPGQSSL 370 YSSPCSQTSS 380 AGSSGGGGGG 390 AGAAGGAGGA 400 GTYHCNLQAM 410 SLYAAGERGG 420 HLQGAPGGAG 430 GSAVDDPLPD 440 YSLPPVTSSS 450 SSSLSHGGGG 460 GGGGGGQEAG 470 HHPAAHQGRL 480 TSWYLNQAGG 490 DLGHLASAAA 500 AAAAAGYPGQ 510 QQNFHSVREM 520 FESQRIGLNN 530 SPVNGNSSCQ 540 MAFPSSQSLY 550 RTSGAFVYDC SKF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000792 heterochromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0008301 DNA binding, bending
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0140297 DNA-binding transcription factor binding
Molecular Function GO:1990841 promoter-specific chromatin binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function GO:0043565 sequence-specific DNA binding
Molecular Function GO:0000976 transcription cis-regulatory region binding
Biological Process GO:0009653 anatomical structure morphogenesis
Biological Process GO:0001525 angiogenesis
Biological Process GO:0030154 cell differentiation
Biological Process GO:0016477 cell migration
Biological Process GO:0008283 cell population proliferation
Biological Process GO:1990869 cellular response to chemokine
Biological Process GO:0071364 cellular response to epidermal growth factor stimulus
Biological Process GO:0021549 cerebellum development
Biological Process GO:0070098 chemokine-mediated signaling pathway
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0001958 endochondral ossification
Biological Process GO:0001654 eye development
Biological Process GO:0072010 glomerular epithelium development
Biological Process GO:0007507 heart development
Biological Process GO:0001822 kidney development
Biological Process GO:0036438 maintenance of lens transparency
Biological Process GO:0014031 mesenchymal cell development
Biological Process GO:0016525 negative regulation of angiogenesis
Biological Process GO:1901491 negative regulation of lymphangiogenesis
Biological Process GO:0045930 negative regulation of mitotic cell cycle
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0042475 odontogenesis of dentin-containing tooth
Biological Process GO:0048341 paraxial mesoderm formation
Biological Process GO:1904798 positive regulation of core promoter binding
Biological Process GO:0043388 positive regulation of DNA binding
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0010718 positive regulation of epithelial to mesenchymal transition
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:1901534 positive regulation of hematopoietic progenitor cell differentiation
Biological Process GO:1902038 positive regulation of hematopoietic stem cell differentiation
Biological Process GO:0045618 positive regulation of keratinocyte differentiation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0001756 somitogenesis
Biological Process GO:0001657 ureteric bud development
Biological Process GO:0038084 vascular endothelial growth factor signaling pathway

Reference

PMID: N/A