Search Results

Overview

Uniprot IDQ12955
Protein NameAnkyrin-3
Gene NameANK3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1422 LKEPKTTKGLPQTAV
1888 FLAPSALKLSTPSSL
4327 PCVPVSMKKMSRTSP
4328 CVPVSMKKMSRTSPA

Function

Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity)

Protein Sequence

10 MAHAASQLKK 20 NRDLEINAEE 30 EPEKKRKHRK 40 RSRDRKKKSD 50 ANASYLRAAR 60 AGHLEKALDY 70 IKNGVDINIC 80 NQNGLNALHL 90 ASKEGHVEVV 100 SELLQREANV 110 DAATKKGNTA 120 LHIASLAGQA 130 EVVKVLVTNG 140 ANVNAQSQNG 150 FTPLYMAAQE 160 NHLEVVKFLL 170 DNGASQSLAT 180 EDGFTPLAVA 190 LQQGHDQVVS 200 LLLENDTKGK 210 VRLPALHIAA 220 RKDDTKAAAL 230 LLQNDNNADV 240 ESKSGFTPLH 250 IAAHYGNINV 260 ATLLLNRAAA 270 VDFTARNDIT 280 PLHVASKRGN 290 ANMVKLLLDR 300 GAKIDAKTRD 310 GLTPLHCGAR 320 SGHEQVVEML 330 LDRAAPILSK 340 TKNGLSPLHM 350 ATQGDHLNCV 360 QLLLQHNVPV 370 DDVTNDYLTA 380 LHVAAHCGHY 390 KVAKVLLDKK 400 ANPNAKALNG 410 FTPLHIACKK 420 NRIKVMELLL 430 KHGASIQAVT 440 ESGLTPIHVA 450 AFMGHVNIVS 460 QLMHHGASPN 470 TTNVRGETAL 480 HMAARSGQAE 490 VVRYLVQDGA 500 QVEAKAKDDQ 510 TPLHISARLG 520 KADIVQQLLQ 530 QGASPNAATT 540 SGYTPLHLSA 550 REGHEDVAAF 560 LLDHGASLSI 570 TTKKGFTPLH 580 VAAKYGKLEV 590 ANLLLQKSAS 600 PDAAGKSGLT 610 PLHVAAHYDN 620 QKVALLLLDQ 630 GASPHAAAKN 640 GYTPLHIAAK 650 KNQMDIATTL 660 LEYGADANAV 670 TRQGIASVHL 680 AAQEGHVDMV 690 SLLLGRNANV 700 NLSNKSGLTP 710 LHLAAQEDRV 720 NVAEVLVNQG 730 AHVDAQTKMG 740 YTPLHVGCHY 750 GNIKIVNFLL 760 QHSAKVNAKT 770 KNGYTPLHQA 780 AQQGHTHIIN 790 VLLQNNASPN 800 ELTVNGNTAL 810 GIARRLGYIS 820 VVDTLKIVTE 830 ETMTTTTVTE 840 KHKMNVPETM 850 NEVLDMSDDE 860 VRKANAPEML 870 SDGEYISDVE 880 EGEDAMTGDT 890 DKYLGPQDLK 900 ELGDDSLPAE 910 GYMGFSLGAR 920 SASLRSFSSD 930 RSYTLNRSSY 940 ARDSMMIEEL 950 LVPSKEQHLT 960 FTREFDSDSL 970 RHYSWAADTL 980 DNVNLVSSPI 990 HSGFLVSFMV 1000 DARGGSMRGS 1010 RHHGMRIIIP 1020 PRKCTAPTRI 1030 TCRLVKRHKL 1040 ANPPPMVEGE 1050 GLASRLVEMG 1060 PAGAQFLGPV 1070 IVEIPHFGSM 1080 RGKERELIVL 1090 RSENGETWKE 1100 HQFDSKNEDL 1110 TELLNGMDEE 1120 LDSPEELGKK 1130 RICRIITKDF 1140 PQYFAVVSRI 1150 KQESNQIGPE 1160 GGILSSTTVP 1170 LVQASFPEGA 1180 LTKRIRVGLQ 1190 AQPVPDEIVK 1200 KILGNKATFS 1210 PIVTVEPRRR 1220 KFHKPITMTI 1230 PVPPPSGEGV 1240 SNGYKGDTTP 1250 NLRLLCSITG 1260 GTSPAQWEDI 1270 TGTTPLTFIK 1280 DCVSFTTNVS 1290 ARFWLADCHQ 1300 VLETVGLATQ 1310 LYRELICVPY 1320 MAKFVVFAKM 1330 NDPVESSLRC 1340 FCMTDDKVDK 1350 TLEQQENFEE 1360 VARSKDIEVL 1370 EGKPIYVDCY 1380 GNLAPLTKGG 1390 QQLVFNFYSF 1400 KENRLPFSIK 1410 IRDTSQEPCG 1420 RLSFLKEPKT 1430 TKGLPQTAVC 1440 NLNITLPAHK 1450 KETESDQDDE 1460 IEKTDRRQSF 1470 ASLALRKRYS 1480 YLTEPGMIER 1490 STGATRSLPT 1500 TYSYKPFFST 1510 RPYQSWTTAP 1520 ITVPGPAKSG 1530 FTSLSSSSSN 1540 TPSASPLKSI 1550 WSVSTPSPIK 1560 STLGASTTSS 1570 VKSISDVASP 1580 IRSFRTMSSP 1590 IKTVVSQSPY 1600 NIQVSSGTLA 1610 RAPAVTEATP 1620 LKGLASNSTF 1630 SSRTSPVTTA 1640 GSLLERSSIT 1650 MTPPASPKSN 1660 INMYSSSLPF 1670 KSIITSAAPL 1680 ISSPLKSVVS 1690 PVKSAVDVIS 1700 SAKITMASSL 1710 SSPVKQMPGH 1720 AEVALVNGSI 1730 SPLKYPSSST 1740 LINGCKATAT 1750 LQEKISSATN 1760 SVSSVVSAAT 1770 DTVEKVFSTT 1780 TAMPFSPLRS 1790 YVSAAPSAFQ 1800 SLRTPSASAL 1810 YTSLGSSISA 1820 TTSSVTSSII 1830 TVPVYSVVNV 1840 LPEPALKKLP 1850 DSNSFTKSAA 1860 ALLSPIKTLT 1870 TETHPQPHFS 1880 RTSSPVKSSL 1890 FLAPSALKLS 1900 TPSSLSSSQE 1910 ILKDVAEMKE 1920 DLMRMTAILQ 1930 TDVPEEKPFQ 1940 PELPKEGRID 1950 DEEPFKIVEK 1960 VKEDLVKVSE 1970 ILKKDVCVDN 1980 KGSPKSPKSD 1990 KGHSPEDDWI 2000 EFSSEEIREA 2010 RQQAAASQSP 2020 SLPERVQVKA 2030 KAASEKDYNL 2040 TKVIDYLTND 2050 IGSSSLTNLK 2060 YKFEDAKKDG 2070 EERQKRVLKP 2080 AIALQEHKLK 2090 MPPASMRTST 2100 SEKELCKMAD 2110 SFFGTDTILE 2120 SPDDFSQHDQ 2130 DKSPLSDSGF 2140 ETRSEKTPSA 2150 PQSAESTGPK 2160 PLFHEVPIPP 2170 VITETRTEVV 2180 HVIRSYDPSA 2190 GDVPQTQPEE 2200 PVSPKPSPTF 2210 MELEPKPTTS 2220 SIKEKVKAFQ 2230 MKASSEEDDH 2240 NRVLSKGMRV 2250 KEETHITTTT 2260 RMVYHSPPGG 2270 EGASERIEET 2280 MSVHDIMKAF 2290 QSGRDPSKEL 2300 AGLFEHKSAV 2310 SPDVHKSAAE 2320 TSAQHAEKDN 2330 QMKPKLERII 2340 EVHIEKGNQA 2350 EPTEVIIRET 2360 KKHPEKEMYV 2370 YQKDLSRGDI 2380 NLKDFLPEKH 2390 DAFPCSEEQG 2400 QQEEEELTAE 2410 ESLPSYLESS 2420 RVNTPVSQEE 2430 DSRPSSAQLI 2440 SDDSYKTLKL 2450 LSQHSIEYHD 2460 DELSELRGES 2470 YRFAEKMLLS 2480 EKLDVSHSDT 2490 EESVTDHAGP 2500 PSSELQGSDK 2510 RSREKIATAP 2520 KKEILSKIYK 2530 DVSENGVGKV 2540 SKDEHFDKVT 2550 VLHYSGNVSS 2560 PKHAMWMRFT 2570 EDRLDRGREK 2580 LIYEDRVDRT 2590 VKEAEEKLTE 2600 VSQFFRDKTE 2610 KLNDELQSPE 2620 KKARPKNGKE 2630 YSSQSPTSSS 2640 PEKVLLTELL 2650 ASNDEWVKAR 2660 QHGPDGQGFP 2670 KAEEKAPSLP 2680 SSPEKMVLSQ 2690 QTEDSKSTVE 2700 AKGSISQSKA 2710 PDGPQSGFQL 2720 KQSKLSSIRL 2730 KFEQGTHAKS 2740 KDMSQEDRKS 2750 DGQSRIPVKK 2760 IQESKLPVYQ 2770 VFAREKQQKA 2780 IDLPDESVSV 2790 QKDFMVLKTK 2800 DEHAQSNEIV 2810 VNDSGSDNVK 2820 KQRTEMSSKA 2830 MPDSFSEQQA 2840 KDLACHITSD 2850 LATRGPWDKK 2860 VFRTWESSGA 2870 TNNKSQKEKL 2880 SHVLVHDVRE 2890 NHIGHPESKS 2900 VDQKNEFMSV 2910 TERERKLLTN 2920 GSLSEIKEMT 2930 VKSPSKKVLY 2940 REYVVKEGDH 2950 PGGLLDQPSR 2960 RSESSAVSHI 2970 PVRVADERRM 2980 LSSNIPDGFC 2990 EQSAFPKHEL 3000 SQKLSQSSMS 3010 KETVETQHFN 3020 SIEDEKVTYS 3030 EISKVSKHQS 3040 YVGLCPPLEE 3050 TETSPTKSPD 3060 SLEFSPGKES 3070 PSSDVFDHSP 3080 IDGLEKLAPL 3090 AQTEGGKEIK 3100 TLPVYVSFVQ 3110 VGKQYEKEIQ 3120 QGGVKKIISQ 3130 ECKTVQETRG 3140 TFYTTRQQKQ 3150 PPSPQGSPED 3160 DTLEQVSFLD 3170 SSGKSPLTPE 3180 TPSSEEVSYE 3190 FTSKTPDSLI 3200 AYIPGKPSPI 3210 PEVSEESEEE 3220 EQAKSTSLKQ 3230 TTVEETAVER 3240 EMPNDVSKDS 3250 NQRPKNNRVA 3260 YIEFPPPPPL 3270 DADQIESDKK 3280 HHYLPEKEVD 3290 MIEVNLQDEH 3300 DKYQLAEPVI 3310 RVQPPSPVPP 3320 GADVSDSSDD 3330 ESIYQPVPVK 3340 KYTFKLKEVD 3350 DEQKEKPKAS 3360 AEKASNQKEL 3370 ESNGSGKDNE 3380 FGLGLDSPQN 3390 EIAQNGNNDQ 3400 SITECSIATT 3410 AEFSHDTDAT 3420 EIDSLDGYDL 3430 QDEDDGLTES 3440 DSKLPIQAME 3450 IKKDIWNTEG 3460 ILKPADRSFS 3470 QSKLEVIEEE 3480 GKVGPDEDKP 3490 PSKSSSSEKT 3500 PDKTDQKSGA 3510 QFFTLEGRHP 3520 DRSVFPDTYF 3530 SYKVDEEFAT 3540 PFKTVATKGL 3550 DFDPWSNNRG 3560 DDEVFDSKSR 3570 EDETKPFGLA 3580 VEDRSPATTP 3590 DTTPARTPTD 3600 ESTPTSEPNP 3610 FPFHEGKMFE 3620 MTRSGAIDMS 3630 KRDFVEERLQ 3640 FFQIGEHTSE 3650 GKSGDQGEGD 3660 KSMVTATPQP 3670 QSGDTTVETN 3680 LERNVETPTV 3690 EPNPSIPTSG 3700 ECQEGTSSSG 3710 SLEKSAAATN 3720 TSKVDPKLRT 3730 PIKMGISAST 3740 MTMKKEGPGE 3750 ITDKIEAVMT 3760 SCQGLENETI 3770 TMISNTANSQ 3780 MGVRPHEKHD 3790 FQKDNFNNNN 3800 NLDSSTIQTD 3810 NIMSNIVLTE 3820 HSAPTCTTEK 3830 DNPVKVSSGK 3840 KTGVLQGHCV 3850 RDKQKVLGEQ 3860 QKTKELIGIR 3870 QKSKLPIKAT 3880 SPKDTFPPNH 3890 MSNTKASKMK 3900 QVSQSEKTKA 3910 LTTSSCVDVK 3920 SRIPVKNTHR 3930 DNIIAVRKAC 3940 ATQKQGQPEK 3950 GKAKQLPSKL 3960 PVKVRSTCVT 3970 TTTTTATTTT 3980 TTTTTTTTSC 3990 TVKVRKSQLK 4000 EVCKHSIEYF 4010 KGISGETLKL 4020 VDRLSEEEKK 4030 MQSELSDEEE 4040 STSRNTSLSE 4050 TSRGGQPSVT 4060 TKSARDKKTE 4070 AAPLKSKSEK 4080 AGSEKRSSRR 4090 TGPQSPCERT 4100 DIRMAIVADH 4110 LGLSWTELAR 4120 ELNFSVDEIN 4130 QIRVENPNSL 4140 ISQSFMLLKK 4150 WVTRDGKNAT 4160 TDALTSVLTK 4170 INRIDIVTLL 4180 EGPIFDYGNI 4190 SGTRSFADEN 4200 NVFHDPVDGW 4210 QNETSSGNLE 4220 SCAQARRVTG 4230 GLLDRLDDSP 4240 DQCRDSITSY 4250 LKGEAGKFEA 4260 NGSHTEITPE 4270 AKTKSYFPES 4280 QNDVGKQSTK 4290 ETLKPKIHGS 4300 GHVEEPASPL 4310 AAYQKSLEET 4320 SKLIIEETKP 4330 CVPVSMKKMS 4340 RTSPADGKPR 4350 LSLHEEEGSS 4360 GSEQKQGEGF 4370 KVKTKKEIRH VEKKSHS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0043194 axon initial segment
Cellular Component GO:0009925 basal plasma membrane
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0009986 cell surface
Cellular Component GO:0043034 costamere
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030425 dendrite
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0014704 intercalated disc
Cellular Component GO:0016328 lateral plasma membrane
Cellular Component GO:0005764 lysosome
Cellular Component GO:0031594 neuromuscular junction
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0033268 node of Ranvier
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0045211 postsynaptic membrane
Cellular Component GO:0042383 sarcolemma
Cellular Component GO:0016529 sarcoplasmic reticulum
Cellular Component GO:0014731 spectrin-associated cytoskeleton
Cellular Component GO:0030315 T-tubule
Cellular Component GO:0030018 Z disc
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0099103 channel activator activity
Molecular Function GO:0008093 cytoskeletal anchor activity
Molecular Function GO:0008092 cytoskeletal protein binding
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Molecular Function GO:0017080 sodium channel regulator activity
Molecular Function GO:0030507 spectrin binding
Molecular Function GO:0005200 structural constituent of cytoskeleton
Molecular Function GO:0044325 transmembrane transporter binding
Biological Process GO:0007409 axonogenesis
Biological Process GO:0071286 cellular response to magnesium ion
Biological Process GO:0045184 establishment of protein localization
Biological Process GO:0043001 Golgi to plasma membrane protein transport
Biological Process GO:0010960 magnesium ion homeostasis
Biological Process GO:0072660 maintenance of protein location in plasma membrane
Biological Process GO:0071709 membrane assembly
Biological Process GO:0000281 mitotic cytokinesis
Biological Process GO:1902260 negative regulation of delayed rectifier potassium channel activity
Biological Process GO:0007528 neuromuscular junction development
Biological Process GO:0019228 neuronal action potential
Biological Process GO:0007009 plasma membrane organization
Biological Process GO:0010650 positive regulation of cell communication by electrical coupling
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0034112 positive regulation of homotypic cell-cell adhesion
Biological Process GO:1900827 positive regulation of membrane depolarization during cardiac muscle cell action potential
Biological Process GO:0045838 positive regulation of membrane potential
Biological Process GO:0090314 positive regulation of protein targeting to membrane
Biological Process GO:0010765 positive regulation of sodium ion transport
Biological Process GO:0099612 protein localization to axon
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0043266 regulation of potassium ion transport
Biological Process GO:0007165 signal transduction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.