Search Results
Overview
| Uniprot ID | Q12959 |
|---|---|
| Protein Name | Disks large homolog 1 |
| Gene Name | DLG1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 452 | ARYSPVSKAVLGDDE |
Function
Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497)
Protein Sequence
10
MPVRKQDTQR
20
ALHLLEEYRS
30
KLSQTEDRQL
40
RSSIERVINI
50
FQSNLFQALI
60
DIQEFYEVTL
70
LDNPKCIDRS
80
KPSEPIQPVN
90
TWEISSLPSS
100
TVTSETLPSS
110
LSPSVEKYRY
120
QDEDTPPQEH
130
ISPQITNEVI
140
GPELVHVSEK
150
NLSEIENVHG
160
FVSHSHISPI
170
KPTEAVLPSP
180
PTVPVIPVLP
190
VPAENTVILP
200
TIPQANPPPV
210
LVNTDSLETP
220
TYVNGTDADY
230
EYEEITLERG
240
NSGLGFSIAG
250
GTDNPHIGDD
260
SSIFITKIIT
270
GGAAAQDGRL
280
RVNDCILRVN
290
EVDVRDVTHS
300
KAVEALKEAG
310
SIVRLYVKRR
320
KPVSEKIMEI
330
KLIKGPKGLG
340
FSIAGGVGNQ
350
HIPGDNSIYV
360
TKIIEGGAAH
370
KDGKLQIGDK
380
LLAVNNVCLE
390
EVTHEEAVTA
400
LKNTSDFVYL
410
KVAKPTSMYM
420
NDGYAPPDIT
430
NSSSQPVDNH
440
VSPSSFLGQT
450
PASPARYSPV
460
SKAVLGDDEI
470
TREPRKVVLH
480
RGSTGLGFNI
490
VGGEDGEGIF
500
ISFILAGGPA
510
DLSGELRKGD
520
RIISVNSVDL
530
RAASHEQAAA
540
ALKNAGQAVT
550
IVAQYRPEEY
560
SRFEAKIHDL
570
REQMMNSSIS
580
SGSGSLRTSQ
590
KRSLYVRALF
600
DYDKTKDSGL
610
PSQGLNFKFG
620
DILHVINASD
630
DEWWQARQVT
640
PDGESDEVGV
650
IPSKRRVEKK
660
ERARLKTVKF
670
NSKTRDKGEI
680
PDDMGSKGLK
690
HVTSNASDSE
700
SSYRGQEEYV
710
LSYEPVNQQE
720
VNYTRPVIIL
730
GPMKDRINDD
740
LISEFPDKFG
750
SCVPHTTRPK
760
RDYEVDGRDY
770
HFVTSREQME
780
KDIQEHKFIE
790
AGQYNNHLYG
800
TSVQSVREVA
810
EKGKHCILDV
820
SGNAIKRLQI
830
AQLYPISIFI
840
KPKSMENIME
850
MNKRLTEEQA
860
RKTFERAMKL
870
EQEFTEHFTA
880
IVQGDTLEDI
890
YNQVKQIIEE
900
QSGSYIWVPA
KEKL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0005912 | adherens junction |
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0005604 | basement membrane |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0005923 | bicellular tight junction |
| Cellular Component | GO:0030054 | cell junction |
| Cellular Component | GO:0031253 | cell projection membrane |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0001772 | immunological synapse |
| Cellular Component | GO:0014704 | intercalated disc |
| Cellular Component | GO:0043219 | lateral loop |
| Cellular Component | GO:0016328 | lateral plasma membrane |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0097025 | MPP7-DLG1-LIN7 complex |
| Cellular Component | GO:0035748 | myelin sheath abaxonal region |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0033268 | node of Ranvier |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098839 | postsynaptic density membrane |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0097060 | synaptic membrane |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0008092 | cytoskeletal protein binding |
| Molecular Function | GO:0004385 | GMP kinase activity |
| Molecular Function | GO:0035255 | ionotropic glutamate receptor binding |
| Molecular Function | GO:0019900 | kinase binding |
| Molecular Function | GO:0097016 | L27 domain binding |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0019902 | phosphatase binding |
| Molecular Function | GO:0004721 | phosphoprotein phosphatase activity |
| Molecular Function | GO:0015459 | potassium channel regulator activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0098919 | structural constituent of postsynaptic density |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0030953 | astral microtubule organization |
| Biological Process | GO:0070830 | bicellular tight junction assembly |
| Biological Process | GO:0098609 | cell-cell adhesion |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0030866 | cortical actin cytoskeleton organization |
| Biological Process | GO:0043622 | cortical microtubule organization |
| Biological Process | GO:0001935 | endothelial cell proliferation |
| Biological Process | GO:0051660 | establishment of centrosome localization |
| Biological Process | GO:0007163 | establishment or maintenance of cell polarity |
| Biological Process | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity |
| Biological Process | GO:0098915 | membrane repolarization during ventricular cardiac muscle cell action potential |
| Biological Process | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle |
| Biological Process | GO:1903753 | negative regulation of p38MAPK cascade |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0099645 | neurotransmitter receptor localization to postsynaptic specialization membrane |
| Biological Process | GO:0043268 | positive regulation of potassium ion transport |
| Biological Process | GO:1903078 | positive regulation of protein localization to plasma membrane |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0035418 | protein localization to synapse |
| Biological Process | GO:0031503 | protein-containing complex localization |
| Biological Process | GO:0043113 | receptor clustering |
| Biological Process | GO:0097120 | receptor localization to synapse |
| Biological Process | GO:0008360 | regulation of cell shape |
| Biological Process | GO:0042391 | regulation of membrane potential |
| Biological Process | GO:0099072 | regulation of postsynaptic membrane neurotransmitter receptor levels |
| Biological Process | GO:1903764 | regulation of potassium ion export across plasma membrane |
| Biological Process | GO:1903286 | regulation of potassium ion import |
| Biological Process | GO:1902473 | regulation of protein localization to synapse |
| Biological Process | GO:1902305 | regulation of sodium ion transmembrane transport |
| Biological Process | GO:0098911 | regulation of ventricular cardiac muscle cell action potential |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.