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Overview

Uniprot IDQ12965
Protein NameUnconventional myosin-Ie
Gene NameMYO1E
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
578 DLVSTLMKCTPHYIR

Function

Actin-based motor molecule with ATPase activity (PubMed:11940582, PubMed:36316095). Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Involved in clathrin-mediated endocytosis and intracellular movement of clathrin-coated vesicles (PubMed:36316095). Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14

Protein Sequence

10 MGSKGVYQYH 20 WQSHNVKHSG 30 VDDMVLLSKI 40 TENSIVENLK 50 KRYMDDYIFT 60 YIGSVLISVN 70 PFKQMPYFGE 80 KEIEMYQGAA 90 QYENPPHIYA 100 LADNMYRNMI 110 IDRENQCVII 120 SGESGAGKTV 130 AAKYIMSYIS 140 RVSGGGTKVQ 150 HVKDIILQSN 160 PLLEAFGNAK 170 TVRNNNSSRF 180 GKYFEIQFSP 190 GGEPDGGKIS 200 NFLLEKSRVV 210 MRNPGERSFH 220 IFYQLIEGAS 230 AEQKHSLGIT 240 SMDYYYYLSL 250 SGSYKVDDID 260 DRREFQETLH 270 AMNVIGIFAE 280 EQTLVLQIVA 290 GILHLGNISF 300 KEVGNYAAVE 310 SEEFLAFPAY 320 LLGINQDRLK 330 EKLTSRQMDS 340 KWGGKSESIH 350 VTLNVEQACY 360 TRDALAKALH 370 ARVFDFLVDS 380 INKAMEKDHE 390 EYNIGVLDIY 400 GFEIFQKNGF 410 EQFCINFVNE 420 KLQQIFIELT 430 LKAEQEEYVQ 440 EGIRWTPIEY 450 FNNKIVCDLI 460 ENKVNPPGIM 470 SILDDVCATM 480 HAVGEGADQT 490 LLQKLQMQIG 500 SHEHFNSWNQ 510 GFIIHHYAGK 520 VSYDMDGFCE 530 RNRDVLFMDL 540 IELMQSSELP 550 FIKSLFPENL 560 QADKKGRPTT 570 AGSKIKKQAN 580 DLVSTLMKCT 590 PHYIRCIKPN 600 ETKKPRDWEE 610 SRVKHQVEYL 620 GLKENIRVRR 630 AGYAYRRIFQ 640 KFLQRYAILT 650 KATWPSWQGE 660 EKQGVLHLLQ 670 SVNMDSDQFQ 680 LGRSKVFIKA 690 PESLFLLEEM 700 RERKYDGYAR 710 VIQKSWRKFV 720 ARKKYVQMRE 730 EASDLLLNKK 740 ERRRNSINRN 750 FIGDYIGMEE 760 HPELQQFVGK 770 REKIDFADTV 780 TKYDRRFKGV 790 KRDLLLTPKC 800 LYLIGREKVK 810 QGPDKGLVKE 820 VLKRKIEIER 830 ILSVSLSTMQ 840 DDIFILHEQE 850 YDSLLESVFK 860 TEFLSLLAKR 870 YEEKTQKQLP 880 LKFSNTLELK 890 LKKENWGPWS 900 AGGSRQVQFH 910 QGFGDLAVLK 920 PSNKVLQVSI 930 GPGLPKNSRP 940 TRRNTTQNTG 950 YSSGTQNANY 960 PVRAAPPPPG 970 YHQNGVIRNQ 980 YVPYPHAPGS 990 QRSNQKSLYT 1000 SMARPPLPRQ 1010 QSTSSDRVSQ 1020 TPESLDFLKV 1030 PDQGAAGVRR 1040 QTTSRPPPAG 1050 GRPKPQPKPK 1060 PQVPQCKALY 1070 AYDAQDTDEL 1080 SFNANDIIDI 1090 IKEDPSGWWT 1100 GRLRGKQGLF PNNYVTKI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005912 adherens junction
Cellular Component GO:0005903 brush border
Cellular Component GO:0030136 clathrin-coated vesicle
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005902 microvillus
Cellular Component GO:0016459 myosin complex
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0000146 microfilament motor activity
Molecular Function GO:0035091 phosphatidylinositol binding
Biological Process GO:0007015 actin filament organization
Biological Process GO:0006897 endocytosis
Biological Process GO:0032836 glomerular basement membrane development
Biological Process GO:0003094 glomerular filtration
Biological Process GO:0032835 glomerulus development
Biological Process GO:0072015 podocyte development

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.