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Overview

Uniprot IDQ12968
Protein NameNuclear factor of activated T-cells, cytoplasmic 3
Gene NameNFATC3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
504 QVHRITGKTVATASQ

Function

Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels

Protein Sequence

10 MTTANCGAHD 20 ELDFKLVFGE 30 DGAPAPPPPG 40 SRPADLEPDD 50 CASIYIFNVD 60 PPPSTLTTPL 70 CLPHHGLPSH 80 SSVLSPSFQL 90 QSHKNYEGTC 100 EIPESKYSPL 110 GGPKPFECPS 120 IQITSISPNC 130 HQELDAHEDD 140 LQINDPEREF 150 LERPSRDHLY 160 LPLEPSYRES 170 SLSPSPASSI 180 SSRSWFSDAS 190 SCESLSHIYD 200 DVDSELNEAA 210 ARFTLGSPLT 220 SPGGSPGGCP 230 GEETWHQQYG 240 LGHSLSPRQS 250 PCHSPRSSVT 260 DENWLSPRPA 270 SGPSSRPTSP 280 CGKRRHSSAE 290 VCYAGSLSPH 300 HSPVPSPGHS 310 PRGSVTEDTW 320 LNASVHGGSG 330 LGPAVFPFQY 340 CVETDIPLKT 350 RKTSEDQAAI 360 LPGKLELCSD 370 DQGSLSPARE 380 TSIDDGLGSQ 390 YPLKKDSCGD 400 QFLSVPSPFT 410 WSKPKPGHTP 420 IFRTSSLPPL 430 DWPLPAHFGQ 440 CELKIEVQPK 450 THHRAHYETE 460 GSRGAVKAST 470 GGHPVVKLLG 480 YNEKPINLQM 490 FIGTADDRYL 500 RPHAFYQVHR 510 ITGKTVATAS 520 QEIIIASTKV 530 LEIPLLPENN 540 MSASIDCAGI 550 LKLRNSDIEL 560 RKGETDIGRK 570 NTRVRLVFRV 580 HIPQPSGKVL 590 SLQIASIPVE 600 CSQRSAQELP 610 HIEKYSINSC 620 SVNGGHEMVV 630 TGSNFLPESK 640 IIFLEKGQDG 650 RPQWEVEGKI 660 IREKCQGAHI 670 VLEVPPYHNP 680 AVTAAVQVHF 690 YLCNGKRKKS 700 QSQRFTYTPV 710 LMKQEHREEI 720 DLSSVPSLPV 730 PHPAQTQRPS 740 SDSGCSHDSV 750 LSGQRSLICS 760 IPQTYASMVT 770 SSHLPQLQCR 780 DESVSKEQHM 790 IPSPIVHQPF 800 QVTPTPPVGS 810 SYQPMQTNVV 820 YNGPTCLPIN 830 AASSQEFDSV 840 LFQQDATLSG 850 LVNLGCQPLS 860 SIPFHSSNSG 870 STGHLLAHTP 880 HSVHTLPHLQ 890 SMGYHCSNTG 900 QRSLSSPVAD 910 QITGQPSSQL 920 QPITYGPSHS 930 GSATTASPAA 940 SHPLASSPLS 950 GPPSPQLQPM 960 PYQSPSSGTA 970 SSPSPATRMH 980 SGQHSTQAQS 990 TGQGGLSAPS 1000 SLICHSLCDP 1010 ASFPPDGATV 1020 SIKPEPEDRE 1030 PNFATIGLQD 1040 ITLDDVNEII 1050 GRDMSQISVS 1060 QGAGVSRQAP 1070 LPSPESLDLG RSDGL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005667 transcription regulator complex
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:1990837 sequence-specific double-stranded DNA binding
Biological Process GO:0033173 calcineurin-NFAT signaling cascade
Biological Process GO:1904157 DN4 thymocyte differentiation
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006954 inflammatory response
Biological Process GO:1902894 negative regulation of miRNA transcription
Biological Process GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation
Biological Process GO:1905653 positive regulation of artery morphogenesis
Biological Process GO:0045429 positive regulation of nitric oxide biosynthetic process
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0045059 positive thymic T cell selection
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.