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Overview

Uniprot IDQ12986
Protein NameTranscriptional repressor NF-X1
Gene NameNFX1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
120 KHHIRVKKAQSLAEQ
305 ENLAVINKSSRRVDQ

Function

Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination

Protein Sequence

10 MAEAPPVSGT 20 FKFNTDAAEF 30 IPQEKKNSGL 40 NCGTQRRLDS 50 NRIGRRNYSS 60 PPPCHLSRQV 70 PYDEISAVHQ 80 HSYHPSGSKP 90 KSQQTSFQSS 100 PCNKSPKSHG 110 LQNQPWQKLR 120 NEKHHIRVKK 130 AQSLAEQTSD 140 TAGLESSTRS 150 ESGTDLREHS 160 PSESEKEVVG 170 ADPRGAKPKK 180 ATQFVYSYGR 190 GPKVKGKLKC 200 EWSNRTTPKP 210 EDAGPESTKP 220 VGVFHPDSSE 230 ASSRKGVLDG 240 YGARRNEQRR 250 YPQKRPPWEV 260 EGARPRPGRN 270 PPKQEGHRHT 280 NAGHRNNMGP 290 IPKDDLNERP 300 AKSTCDSENL 310 AVINKSSRRV 320 DQEKCTVRRQ 330 DPQVVSPFSR 340 GKQNHVLKNV 350 ETHTGSLIEQ 360 LTTEKYECMV 370 CCELVRVTAP 380 VWSCQSCYHV 390 FHLNCIKKWA 400 RSPASQADGQ 410 SGWRCPACQN 420 VSAHVPNTYT 430 CFCGKVKNPE 440 WSRNEIPHSC 450 GEVCRKKQPG 460 QDCPHSCNLL 470 CHPGPCPPCP 480 AFMTKTCECG 490 RTRHTVRCGQ 500 AVSVHCSNPC 510 ENILNCGQHQ 520 CAELCHGGQC 530 QPCQIILNQV 540 CYCGSTSRDV 550 LCGTDVGKSD 560 GFGDFSCLKI 570 CGKDLKCGNH 580 TCSQVCHPQP 590 CQQCPRLPQL 600 VRCCPCGQTP 610 LSQLLELGSS 620 SRKTCMDPVP 630 SCGKVCGKPL 640 PCGSLDFIHT 650 CEKLCHEGDC 660 GPCSRTSVIS 670 CRCSFRTKEL 680 PCTSLKSEDA 690 TFMCDKRCNK 700 KRLCGRHKCN 710 EICCVDKEHK 720 CPLICGRKLR 730 CGLHRCEEPC 740 HRGNCQTCWQ 750 ASFDELTCHC 760 GASVIYPPVP 770 CGTRPPECTQ 780 TCARVHECDH 790 PVYHSCHSEE 800 KCPPCTFLTQ 810 KWCMGKHEFR 820 SNIPCHLVDI 830 SCGLPCSATL 840 PCGMHKCQRL 850 CHKGECLVDE 860 PCKQPCTTPR 870 ADCGHPCMAP 880 CHTSSPCPVT 890 ACKAKVELQC 900 ECGRRKEMVI 910 CSEASSTYQR 920 IAAISMASKI 930 TDMQLGGSVE 940 ISKLITKKEV 950 HQARLECDEE 960 CSALERKKRL 970 AEAFHISEDS 980 DPFNIRSSGS 990 KFSDSLKEDA 1000 RKDLKFVSDV 1010 EKEMETLVEA 1020 VNKGKNSKKS 1030 HSFPPMNRDH 1040 RRIIHDLAQV 1050 YGLESVSYDS 1060 EPKRNVVVTA 1070 IRGKSVCPPT 1080 TLTGVLEREM 1090 QARPPPPIPH 1100 HRHQSDKNPG 1110 SSNLQKITKE 1120 PIIDYFDVQD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function GO:0061630 ubiquitin protein ligase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006954 inflammatory response
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0051865 protein autoubiquitination
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0006366 transcription by RNA polymerase II

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.