Search Results

Overview

Uniprot ID	Q13009
Protein Name	Rho guanine nucleotide exchange factor TIAM1
Gene Name	TIAM1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1469	VSASSPEKESQQPPG

Function

Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration

Protein Sequence

10 MGNAESQHVE 20 HEFYGEKHAS 30 LGRKHTSRSL 40 RLSHKTRRTR 50 HASSGKVIHR 60 NSEVSTRSSS 70 TPSIPQSLAE 80 NGLEPFSQDG 90 TLEDFGSPIW 100 VDRVDMGLRP 110 VSYTDSSVTP 120 SVDSSIVLTA 130 ASVQSMPDTE 140 ESRLYGDDAT 150 YLAEGGRRQH 160 SYTSNGPTFM 170 ETASFKKKRS 180 KSADIWREDS 190 LEFSLSDLSQ 200 EHLTSNEEIL 210 GSAEEKDCEE 220 ARGMETRASP 230 RQLSTCQRAN 240 SLGDLYAQKN 250 SGVTANGGPG 260 SKFAGYCRNL 270 VSDIPNLANH 280 KMPPAAAEET 290 PPYSNYNTLP 300 CRKSHCLSEG 310 ATNPQISHSN 320 SMQGRRAKTT 330 QDVNAGEGSE 340 FADSGIEGAT 350 TDTDLLSRRS 360 NATNSSYSPT 370 TGRAFVGSDS 380 GSSSTGDAAR 390 QGVYENFRRE 400 LEMSTTNSES 410 LEEAGSAHSD 420 EQSSGTLSSP 430 GQSDILLTAA 440 QGTVRKAGAL 450 AVKNFLVHKK 460 NKKVESATRR 470 KWKHYWVSLK 480 GCTLFFYESD 490 GRSGIDHNSI 500 PKHAVWVENS 510 IVQAVPEHPK 520 KDFVFCLSNS 530 LGDAFLFQTT 540 SQTELENWIT 550 AIHSACATAV 560 ARHHHKEDTL 570 RLLKSEIKKL 580 EQKIDMDEKM 590 KKMGEMQLSS 600 VTDSKKKKTI 610 LDQIFVWEQN 620 LEQFQMDLFR 630 FRCYLASLQG 640 GELPNPKRLL 650 AFASRPTKVA 660 MGRLGIFSVS 670 SFHALVAART 680 GETGVRRRTQ 690 AMSRSASKRR 700 SRFSSLWGLD 710 TTSKKKQGRP 720 SINQVFGEGT 730 EAVKKSLEGI 740 FDDIVPDGKR 750 EKEVVLPNVH 760 QHNPDCDIWV 770 HEYFTPSWFC 780 LPNNQPALTV 790 VRPGDTARDT 800 LELICKTHQL 810 DHSAHYLRLK 820 FLIENKMQLY 830 VPQPEEDIYE 840 LLYKEIEICP 850 KVTQSIHIEK 860 SDTAADTYGF 870 SLSSVEEDGI 880 RRLYVNSVKE 890 TGLASKKGLK 900 AGDEILEINN 910 RAADALNSSM 920 LKDFLSQPSL 930 GLLVRTYPEL 940 EEGVELLESP 950 PHRVDGPADL 960 GESPLAFLTS 970 NPGHSLCSEQ 980 GSSAETAPEE 990 TEGPDLESSD 1000 ETDHSSKSTE 1010 QVAAFCRSLH 1020 EMNPSDQSPS 1030 PQDSTGPQLA 1040 TMRQLSDADK 1050 LRKVICELLE 1060 TERTYVKDLN 1070 CLMERYLKPL 1080 QKETFLTQDE 1090 LDVLFGNLTE 1100 MVEFQVEFLK 1110 TLEDGVRLVP 1120 DLEKLEKVDQ 1130 FKKVLFSLGG 1140 SFLYYADRFK 1150 LYSAFCASHT 1160 KVPKVLVKAK 1170 TDTAFKAFLD 1180 AQNPKQQHSS 1190 TLESYLIKPI 1200 QRILKYPLLL 1210 RELFALTDAE 1220 SEEHYHLDVA 1230 IKTMNKVASH 1240 INEMQKIHEE 1250 FGAVFDQLIA 1260 EQTGEKKEVA 1270 DLSMGDLLLH 1280 TTVIWLNPPA 1290 SLGKWKKEPE 1300 LAAFVFKTAV 1310 VLVYKDGSKQ 1320 KKKLVGSHRL 1330 SIYEDWDPFR 1340 FRHMIPTEAL 1350 QVRALASADA 1360 EANAVCEIVH 1370 VKSESEGRPE 1380 RVFHLCCSSP 1390 ESRKDFLKAV 1400 HSILRDKHRR 1410 QLLKTESLPS 1420 SQQYVPFGGK 1430 RLCALKGARP 1440 AMSRAVSAPS 1450 KSLGRRRRRL 1460 ARNRFTIDSD 1470 AVSASSPEKE 1480 SQQPPGGGDT 1490 DRWVEEQFDL 1500 AQYEEQDDIK 1510 ETDILSDDDE 1520 FCESVKGASV 1530 DRDLQERLQA 1540 TSISQRERGR 1550 KTLDSHASRM 1560 AQLKKQAALS 1570 GINGGLESAS 1580 EEVIWVRRED 1590 FAPSRKLNTE I

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030054	cell junction
Cellular Component	GO:0044291	cell-cell contact zone
Cellular Component	GO:0005911	cell-cell junction
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0045202	synapse
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity
Molecular Function	GO:0019900	kinase binding
Molecular Function	GO:0008289	lipid binding
Biological Process	GO:0016477	cell migration
Biological Process	GO:0007160	cell-matrix adhesion
Biological Process	GO:0048013	ephrin receptor signaling pathway
Biological Process	GO:0035567	non-canonical Wnt signaling pathway
Biological Process	GO:0050772	positive regulation of axonogenesis
Biological Process	GO:0030335	positive regulation of cell migration
Biological Process	GO:0008284	positive regulation of cell population proliferation
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition
Biological Process	GO:0065003	protein-containing complex assembly
Biological Process	GO:0016601	Rac protein signal transduction
Biological Process	GO:1904338	regulation of dopaminergic neuron differentiation
Biological Process	GO:0010717	regulation of epithelial to mesenchymal transition
Biological Process	GO:0051056	regulation of small GTPase mediated signal transduction
Biological Process	GO:0007264	small GTPase-mediated signal transduction
Biological Process	GO:0060071	Wnt signaling pathway, planar cell polarity pathway

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.