Search Results

Overview

Uniprot ID	Q13017
Protein Name	Rho GTPase-activating protein 5
Gene Name	ARHGAP5
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1053	VPKTNVKKLDPNLLK
1245	KKQKKKTKNFNPPTR
709	NQRDSISKNLPILRH

Function

GTPase-activating protein for Rho family members (PubMed:8537347)

Protein Sequence

10 MMAKNKEPRP 20 PSYTISIVGL 30 SGTEKDKGNC 40 GVGKSCLCNR 50 FVRSKADEYY 60 PEHTSVLSTI 70 DFGGRVVNND 80 HFLYWGDIIQ 90 NSEDGVECKI 100 HVIEQTEFID 110 DQTFLPHRST 120 NLQPYIKRAA 130 ASKLQSAEKL 140 MYICTDQLGL 150 EQDFEQKQMP 160 EGKLNVDGFL 170 LCIDVSQGCN 180 RKFDDQLKFV 190 NNLFVQLSKS 200 KKPVIIAATK 210 CDECVDHYLR 220 EVQAFASNKK 230 NLLVVETSAR 240 FNVNIETCFT 250 ALVQMLDKTR 260 SKPKIIPYLD 270 AYKTQRQLVV 280 TATDKFEKLV 290 QTVRDYHATW 300 KTVSNKLKNH 310 PDYEEYINLE 320 GTRKARNTFS 330 KHIEQLKQEH 340 IRKRREEYIN 350 TLPRAFNTLL 360 PNLEEIEHLN 370 WSEALKLMEK 380 RADFQLCFVV 390 LEKTPWDETD 400 HIDKINDRRI 410 PFDLLSTLEA 420 EKVYQNHVQH 430 LISEKRRVEM 440 KEKFKKTLEK 450 IQFISPGQPW 460 EEVMCFVMED 470 EAYKYITEAD 480 SKEVYGRHQR 490 EIVEKAKEEF 500 QEMLFEHSEL 510 FYDLDLNATP 520 SSDKMSEIHT 530 VLSEEPRYKA 540 LQKLAPDRES 550 LLLKHIGFVY 560 HPTKETCLSG 570 QNCTDIKVEQ 580 LLASSLLQLD 590 HGRLRLYHDS 600 TNIDKVNLFI 610 LGKDGLAQEL 620 ANEIRTQSTD 630 DEYALDGKIY 640 ELDLRPVDAK 650 SPYFLSQLWT 660 AAFKPHGCFC 670 VFNSIESLSF 680 IGEFIGKIRT 690 EASQIRKDKY 700 MANLPFTLIL 710 ANQRDSISKN 720 LPILRHQGQQ 730 LANKLQCPFV 740 DVPAGTYPRK 750 FNETQIKQAL 760 RGVLESVKHN 770 LDVVSPIPAN 780 KDLSEADLRI 790 VMCAMCGDPF 800 SVDLILSPFL 810 DSHSCSAAQA 820 GQNNSLMLDK 830 IIGEKRRRIQ 840 ITILSYHSSI 850 GVRKDELVHG 860 YILVYSAKRK 870 ASMGMLRAFL 880 SEVQDTIPVQ 890 LVAVTDSQAD 900 FFENEAIKEL 910 MTEGEHIATE 920 ITAKFTALYS 930 LSQYHRQTEV 940 FTLFFSDVLE 950 KKNMIENSYL 960 SDNTRESTHQ 970 SEDVFLPSPR 980 DCFPYNNYPD 990 SDDDTEAPPP 1000 YSPIGDDVQL 1010 LPTPSDRSRY 1020 RLDLEGNEYP 1030 IHSTPNCHDH 1040 ERNHKVPPPI 1050 KPKPVVPKTN 1060 VKKLDPNLLK 1070 TIEAGIGKNP 1080 RKQTSRVPLA 1090 HPEDMDPSDN 1100 YAEPIDTIFK 1110 QKGYSDEIYV 1120 VPDDSQNRIK 1130 IRNSFVNNTQ 1140 GDEENGFSDR 1150 TSKSHGERRP 1160 SKYKYKSKTL 1170 FSKAKSYYRR 1180 THSDASDDEA 1190 FTTSKTKRKG 1200 RHRGSEEDPL 1210 LSPVETWKGG 1220 IDNPAITSDQ 1230 ELDDKKMKKK 1240 THKVKEDKKQ 1250 KKKTKNFNPP 1260 TRRNWESNYF 1270 GMPLQDLVTA 1280 EKPIPLFVEK 1290 CVEFIEDTGL 1300 CTEGLYRVSG 1310 NKTDQDNIQK 1320 QFDQDHNINL 1330 VSMEVTVNAV 1340 AGALKAFFAD 1350 LPDPLIPYSL 1360 HPELLEAAKI 1370 PDKTERLHAL 1380 KEIVKKFHPV 1390 NYDVFRYVIT 1400 HLNRVSQQHK 1410 INLMTADNLS 1420 ICFWPTLMRP 1430 DFENREFLST 1440 TKIHQSVVET 1450 FIQQCQFFFY 1460 NGEIVETTNI 1470 VAPPPPSNPG 1480 QLVEPMVPLQ 1490 LPPPLQPQLI 1500 QPQLQTDPLG II

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0005096	GTPase activator activity
Molecular Function	GO:0003924	GTPase activity
Molecular Function	GO:0042169	SH2 domain binding
Biological Process	GO:0007155	cell adhesion
Biological Process	GO:0030879	mammary gland development
Biological Process	GO:0008361	regulation of cell size
Biological Process	GO:0051056	regulation of small GTPase mediated signal transduction
Biological Process	GO:0007266	Rho protein signal transduction

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.