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Overview

Uniprot IDQ13029
Protein NamePR domain zinc finger protein 2
Gene NamePRDM2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1368 KKRYTPKKNPVPLKQ
1418 KMSSNKLKLNALKKK
1431 KKNQLVQKAILQKNK
1438 KAILQKNKSAKQKAD
1564 VKFAASVKSKKPSSS
1597 KKPKAVAKNHSAQLS
1606 HSAQLSSKTSRSLHV
1625 SKAVLQSKSTLASKK
486 VKELHPCKYCKKVFG
490 HPCKYCKKVFGTHTN
513 HERHLIPKGVRRKGG
52 WATKPILKGKKFGPF
54 TKPILKGKKFGPFVG
55 KPILKGKKFGPFVGD
774 GLTSKKSKLESHSDS
879 QPTCSAVKKRKPTTC

Function

S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene

Protein Sequence

10 MNQNTTEPVA 20 ATETLAEVPE 30 HVLRGLPEEV 40 RLFPSAVDKT 50 RIGVWATKPI 60 LKGKKFGPFV 70 GDKKKRSQVK 80 NNVYMWEVYY 90 PNLGWMCIDA 100 TDPEKGNWLR 110 YVNWACSGEE 120 QNLFPLEINR 130 AIYYKTLKPI 140 APGEELLVWY 150 NGEDNPEIAA 160 AIEEERASAR 170 SKRSSPKSRK 180 GKKKSQENKN 190 KGNKIQDIQL 200 KTSEPDFTSA 210 NMRDSAEGPK 220 EDEEKPSASA 230 LEQPATLQEV 240 ASQEVPPELA 250 TPAPAWEPQP 260 EPDERLEAAA 270 CEVNDLGEEE 280 EEEEEEDEEE 290 EEDDDDDELE 300 DEGEEEASMP 310 NENSVKEPEI 320 RCDEKPEDLL 330 EEPKTTSEET 340 LEDCSEVTPA 350 MQIPRTKEEA 360 NGDVFETFMF 370 PCQHCERKFT 380 TKQGLERHMH 390 IHISTVNHAF 400 KCKYCGKAFG 410 TQINRRRHER 420 RHEAGLKRKP 430 SQTLQPSEDL 440 ADGKASGENV 450 ASKDDSSPPS 460 LGPDCLIMNS 470 EKASQDTINS 480 SVVEENGEVK 490 ELHPCKYCKK 500 VFGTHTNMRR 510 HQRRVHERHL 520 IPKGVRRKGG 530 LEEPQPPAEQ 540 AQATQNVYVP 550 STEPEEEGEA 560 DDVYIMDISS 570 NISENLNYYI 580 DGKIQTNNNT 590 SNCDVIEMES 600 ASADLYGINC 610 LLTPVTVEIT 620 QNIKTTQVPV 630 TEDLPKEPLG 640 STNSEAKKRR 650 TASPPALPKI 660 KAETDSDPMV 670 PSCSLSLPLS 680 ISTTEAVSFH 690 KEKSVYLSSK 700 LKQLLQTQDK 710 LTPAGISATE 720 IAKLGPVCVS 730 APASMLPVTS 740 SRFKRRTSSP 750 PSSPQHSPAL 760 RDFGKPSDGK 770 AAWTDAGLTS 780 KKSKLESHSD 790 SPAWSLSGRD 800 ERETVSPPCF 810 DEYKMSKEWT 820 ASSAFSSVCN 830 QQPLDLSSGV 840 KQKAEGTGKT 850 PVQWESVLDL 860 SVHKKHCSDS 870 EGKEFKESHS 880 VQPTCSAVKK 890 RKPTTCMLQK 900 VLLNEYNGID 910 LPVENPADGT 920 RSPSPCKSLE 930 AQPDPDLGPG 940 SGFPAPTVES 950 TPDVCPSSPA 960 LQTPSLSSGQ 970 LPPLLIPTDP 980 SSPPPCPPVL 990 TVATPPPPLL 1000 PTVPLPAPSS 1010 SASPHPCPSP 1020 LSNATAQSPL 1030 PILSPTVSPS 1040 PSPIPPVEPL 1050 MSAASPGPPT 1060 LSSSSSSSSS 1070 SSSFSSSSSS 1080 SSPSPPPLSA 1090 ISSVVSSGDN 1100 LEASLPMISF 1110 KQEELENEGL 1120 KPREEPQSAA 1130 EQDVVVQETF 1140 NKNFVCNVCE 1150 SPFLSIKDLT 1160 KHLSIHAEEW 1170 PFKCEFCVQL 1180 FKDKTDLSEH 1190 RFLLHGVGNI 1200 FVCSVCKKEF 1210 AFLCNLQQHQ 1220 RDLHPDKVCT 1230 HHEFESGTLR 1240 PQNFTDPSKA 1250 HVEHMQSLPE 1260 DPLETSKEEE 1270 ELNDSSEELY 1280 TTIKIMASGI 1290 KTKDPDVRLG 1300 LNQHYPSFKP 1310 PPFQYHHRNP 1320 MGIGVTATNF 1330 TTHNIPQTFT 1340 TAIRCTKCGK 1350 GVDNMPELHK 1360 HILACASASD 1370 KKRYTPKKNP 1380 VPLKQTVQPK 1390 NGVVVLDNSG 1400 KNAFRRMGQP 1410 KRLNFSVELS 1420 KMSSNKLKLN 1430 ALKKKNQLVQ 1440 KAILQKNKSA 1450 KQKADLKNAC 1460 ESSSHICPYC 1470 NREFTYIGSL 1480 NKHAAFSCPK 1490 KPLSPPKKKV 1500 SHSSKKGGHS 1510 SPASSDKNSN 1520 SNHRRRTADA 1530 EIKMQSMQTP 1540 LGKTRARSSG 1550 PTQVPLPSSS 1560 FRSKQNVKFA 1570 ASVKSKKPSS 1580 SSLRNSSPIR 1590 MAKITHVEGK 1600 KPKAVAKNHS 1610 AQLSSKTSRS 1620 LHVRVQKSKA 1630 VLQSKSTLAS 1640 KKRTDRFNIK 1650 SRERSGGPVT 1660 RSLQLAAAAD 1670 LSENKREDGS 1680 AKQELKDFSY 1690 SLRLASRCSP 1700 PAAPYITRQY 1710 RKVKAPAAAQ FQGPFFKE

Gene Ontology

Classification GO ID Description
Biological Process GO:0032259 methylation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0140949 histone H3K9 trimethyltransferase activity
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function GO:0043565 sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.