Search Results
Overview
| Uniprot ID | Q13057 |
|---|---|
| Protein Name | Bifunctional coenzyme A synthase |
| Gene Name | COASY |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 185 | SPVAGSPKQPVRGYY |
| 554 | KAWALLQKRIPKTHQ |
Function
Bifunctional enzyme that catalyzes the fourth step of the coenzyme A biosynthetic pathway, the adenylation of 4'-phosphopantetheine, and the fifth step, the phosphorylation of dephospho-CoA to CoA
Protein Sequence
10
MAVFRSGLLV
20
LTTPLASLAP
30
RLASILTSAA
40
RLVNHTLYVH
50
LQPGMSLEGP
60
AQPQSSPVQA
70
TFEVLDFITH
80
LYAGADVHRH
90
LDVRILLTNI
100
RTKSTFLPPL
110
PTSVQNLAHP
120
PEVVLTDFQT
130
LDGSQYNPVK
140
QQLVRYATSC
150
YSCCPRLASV
160
LLYSDYGIGE
170
VPVEPLDVPL
180
PSTIRPASPV
190
AGSPKQPVRG
200
YYRGAVGGTF
210
DRLHNAHKVL
220
LSVACILAQE
230
QLVVGVADKD
240
LLKSKLLPEL
250
LQPYTERVEH
260
LSEFLVDIKP
270
SLTFDVIPLL
280
DPYGPAGSDP
290
SLEFLVVSEE
300
TYRGGMAINR
310
FRLENDLEEL
320
ALYQIQLLKD
330
LRHTENEEDK
340
VSSSSFRQRM
350
LGNLLRPPYE
360
RPELPTCLYV
370
IGLTGISGSG
380
KSSIAQRLKG
390
LGAFVIDSDH
400
LGHRAYAPGG
410
PAYQPVVEAF
420
GTDILHKDGI
430
INRKVLGSRV
440
FGNKKQLKIL
450
TDIMWPIIAK
460
LAREEMDRAV
470
AEGKRVCVID
480
AAVLLEAGWQ
490
NLVHEVWTAV
500
IPETEAVRRI
510
VERDGLSEAA
520
AQSRLQSQMS
530
GQQLVEQSHV
540
VLSTLWEPHI
550
TQRQVEKAWA
560
LLQKRIPKTH
QALD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004140 | dephospho-CoA kinase activity |
| Molecular Function | GO:0004595 | pantetheine-phosphate adenylyltransferase activity |
| Biological Process | GO:0015937 | coenzyme A biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.