Search Results

Overview

Uniprot ID	Q13085
Protein Name	Acetyl-CoA carboxylase 1
Gene Name	ACACA
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
319	ASEGGGGKGIRKVNN
323	GGGKGIRKVNNADDF
86	MSGLHLVKQGRDRKK

Function

Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443)

Protein Sequence

10 MDEPSPLAQP 20 LELNQHSRFI 30 IGSVSEDNSE 40 DEISNLVKLD 50 LLEEKEGSLS 60 PASVGSDTLS 70 DLGISSLQDG 80 LALHIRSSMS 90 GLHLVKQGRD 100 RKKIDSQRDF 110 TVASPAEFVT 120 RFGGNKVIEK 130 VLIANNGIAA 140 VKCMRSIRRW 150 SYEMFRNERA 160 IRFVVMVTPE 170 DLKANAEYIK 180 MADHYVPVPG 190 GPNNNNYANV 200 ELILDIAKRI 210 PVQAVWAGWG 220 HASENPKLPE 230 LLLKNGIAFM 240 GPPSQAMWAL 250 GDKIASSIVA 260 QTAGIPTLPW 270 SGSGLRVDWQ 280 ENDFSKRILN 290 VPQELYEKGY 300 VKDVDDGLQA 310 AEEVGYPVMI 320 KASEGGGGKG 330 IRKVNNADDF 340 PNLFRQVQAE 350 VPGSPIFVMR 360 LAKQSRHLEV 370 QILADQYGNA 380 ISLFGRDCSV 390 QRRHQKIIEE 400 APATIATPAV 410 FEHMEQCAVK 420 LAKMVGYVSA 430 GTVEYLYSQD 440 GSFYFLELNP 450 RLQVEHPCTE 460 MVADVNLPAA 470 QLQIAMGIPL 480 YRIKDIRMMY 490 GVSPWGDSPI 500 DFEDSAHVPC 510 PRGHVIAARI 520 TSENPDEGFK 530 PSSGTVQELN 540 FRSNKNVWGY 550 FSVAAAGGLH 560 EFADSQFGHC 570 FSWGENREEA 580 ISNMVVALKE 590 LSIRGDFRTT 600 VEYLIKLLET 610 ESFQMNRIDT 620 GWLDRLIAEK 630 VQAERPDTML 640 GVVCGALHVA 650 DVSLRNSVSN 660 FLHSLERGQV 670 LPAHTLLNTV 680 DVELIYEGVK 690 YVLKVTRQSP 700 NSYVVIMNGS 710 CVEVDVHRLS 720 DGGLLLSYDG 730 SSYTTYMKEE 740 VDRYRITIGN 750 KTCVFEKEND 760 PSVMRSPSAG 770 KLIQYIVEDG 780 GHVFAGQCYA 790 EIEVMKMVMT 800 LTAVESGCIH 810 YVKRPGAALD 820 PGCVLAKMQL 830 DNPSKVQQAE 840 LHTGSLPRIQ 850 STALRGEKLH 860 RVFHYVLDNL 870 VNVMNGYCLP 880 DPFFSSKVKD 890 WVERLMKTLR 900 DPSLPLLELQ 910 DIMTSVSGRI 920 PPNVEKSIKK 930 EMAQYASNIT 940 SVLCQFPSQQ 950 IANILDSHAA 960 TLNRKSEREV 970 FFMNTQSIVQ 980 LVQRYRSGIR 990 GHMKAVVMDL 1000 LRQYLRVETQ 1010 FQNGHYDKCV 1020 FALREENKSD 1030 MNTVLNYIFS 1040 HAQVTKKNLL 1050 VTMLIDQLCG 1060 RDPTLTDELL 1070 NILTELTQLS 1080 KTTNAKVALR 1090 ARQVLIASHL 1100 PSYELRHNQV 1110 ESIFLSAIDM 1120 YGHQFCIENL 1130 QKLILSETSI 1140 FDVLPNFFYH 1150 SNQVVRMAAL 1160 EVYVRRAYIA 1170 YELNSVQHRQ 1180 LKDNTCVVEF 1190 QFMLPTSHPN 1200 RGNIPTLNRM 1210 SFSSNLNHYG 1220 MTHVASVSDV 1230 LLDNSFTPPC 1240 QRMGGMVSFR 1250 TFEDFVRIFD 1260 EVMGCFSDSP 1270 PQSPTFPEAG 1280 HTSLYDEDKV 1290 PRDEPIHILN 1300 VAIKTDCDIE 1310 DDRLAAMFRE 1320 FTQQNKATLV 1330 DHGIRRLTFL 1340 VAQKDFRKQV 1350 NYEVDRRFHR 1360 EFPKFFTFRA 1370 RDKFEEDRIY 1380 RHLEPALAFQ 1390 LELNRMRNFD 1400 LTAIPCANHK 1410 MHLYLGAAKV 1420 EVGTEVTDYR 1430 FFVRAIIRHS 1440 DLVTKEASFE 1450 YLQNEGERLL 1460 LEAMDELEVA 1470 FNNTNVRTDC 1480 NHIFLNFVPT 1490 VIMDPSKIEE 1500 SVRSMVMRYG 1510 SRLWKLRVLQ 1520 AELKINIRLT 1530 PTGKAIPIRL 1540 FLTNESGYYL 1550 DISLYKEVTD 1560 SRTAQIMFQA 1570 YGDKQGPLHG 1580 MLINTPYVTK 1590 DLLQSKRFQA 1600 QSLGTTYIYD 1610 IPEMFRQSLI 1620 KLWESMSTQA 1630 FLPSPPLPSD 1640 MLTYTELVLD 1650 DQGQLVHMNR 1660 LPGGNEIGMV 1670 AWKMTFKSPE 1680 YPEGRDIIVI 1690 GNDITYRIGS 1700 FGPQEDLLFL 1710 RASELARAEG 1720 IPRIYVSANS 1730 GARIGLAEEI 1740 RHMFHVAWVD 1750 PEDPYKGYRY 1760 LYLTPQDYKR 1770 VSALNSVHCE 1780 HVEDEGESRY 1790 KITDIIGKEE 1800 GIGPENLRGS 1810 GMIAGESSLA 1820 YNEIITISLV 1830 TCRAIGIGAY 1840 LVRLGQRTIQ 1850 VENSHLILTG 1860 AGALNKVLGR 1870 EVYTSNNQLG 1880 GIQIMHNNGV 1890 THCTVCDDFE 1900 GVFTVLHWLS 1910 YMPKSVHSSV 1920 PLLNSKDPID 1930 RIIEFVPTKT 1940 PYDPRWMLAG 1950 RPHPTQKGQW 1960 LSGFFDYGSF 1970 SEIMQPWAQT 1980 VVVGRARLGG 1990 IPVGVVAVET 2000 RTVELSIPAD 2010 PANLDSEAKI 2020 IQQAGQVWFP 2030 DSAFKTYQAI 2040 KDFNREGLPL 2050 MVFANWRGFS 2060 GGMKDMYDQV 2070 LKFGAYIVDG 2080 LRECCQPVLV 2090 YIPPQAELRG 2100 GSWVVIDSSI 2110 NPRHMEMYAD 2120 RESRGSVLEP 2130 EGTVEIKFRR 2140 KDLVKTMRRV 2150 DPVYIHLAER 2160 LGTPELSTAE 2170 RKELENKLKE 2180 REEFLIPIYH 2190 QVAVQFADLH 2200 DTPGRMQEKG 2210 VISDILDWKT 2220 SRTFFYWRLR 2230 RLLLEDLVKK 2240 KIHNANPELT 2250 DGQIQAMLRR 2260 WFVEVEGTVK 2270 AYVWDNNKDL 2280 AEWLEKQLTE 2290 EDGVHSVIEE 2300 NIKCISRDYV 2310 LKQIRSLVQA 2320 NPEVAMDSII 2330 HMTQHISPTQ 2340 RAEVIRILST MDSPST

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0003989	acetyl-CoA carboxylase activity
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0046872	metal ion binding
Biological Process	GO:0006084	acetyl-CoA metabolic process
Biological Process	GO:0006633	fatty acid biosynthetic process
Biological Process	GO:0046949	fatty-acyl-CoA biosynthetic process
Biological Process	GO:2001295	malonyl-CoA biosynthetic process
Biological Process	GO:0051289	protein homotetramerization

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.