Overview
| Uniprot ID | Q13098 |
|---|
| Protein Name | COP9 signalosome complex subunit 1 |
|---|
| Gene Name | GPS1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 150 |
EKLDTDLKNYKGNSI |
| 248 |
QTQAILTKLKCAAGL |
| 337 |
IFKFYESKYASCLKM |
Function
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G protein- and mitogen-activated protein kinase-mediated signal transduction
Protein Sequence
10
MPLPVQVFNL
20
QGAVEPMQID
30
VDPQEDPQNA
40
PDVNYVVENP
50
SLDLEQYAAS
60
YSGLMRIERL
70
QFIADHCPTL
80
RVEALKMALS
90
FVQRTFNVDM
100
YEEIHRKLSE
110
ATRSSLRELQ
120
NAPDAIPESG
130
VEPPALDTAW
140
VEATRKKALL
150
KLEKLDTDLK
160
NYKGNSIKES
170
IRRGHDDLGD
180
HYLDCGDLSN
190
ALKCYSRARD
200
YCTSAKHVIN
210
MCLNVIKVSV
220
YLQNWSHVLS
230
YVSKAESTPE
240
IAEQRGERDS
250
QTQAILTKLK
260
CAAGLAELAA
270
RKYKQAAKCL
280
LLASFDHCDF
290
PELLSPSNVA
300
IYGGLCALAT
310
FDRQELQRNV
320
ISSSSFKLFL
330
ELEPQVRDII
340
FKFYESKYAS
350
CLKMLDEMKD
360
NLLLDMYLAP
370
HVRTLYTQIR
380
NRALIQYFSP
390
YVSADMHRMA
400
AAFNTTVAAL
410
EDELTQLILE
420
GLISARVDSH
430
SKILYARDVD
440
QRSTTFEKSL
450
LMGKEFQRRA
460
KAMMLRAAVL
470
RNQIHVKSPP
480
REGSQGELTP
490
ANSQSRMSTN
M
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008180 |
COP9 signalosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0005095 |
GTPase inhibitor activity |
| Biological Process |
GO:0007254 |
JNK cascade |
| Biological Process |
GO:0000338 |
protein deneddylation |
| Biological Process |
GO:0045116 |
protein neddylation |
| Biological Process |
GO:2000434 |
regulation of protein neddylation |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.