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Overview

Uniprot IDQ13111
Protein NameChromatin assembly factor 1 subunit A
Gene NameCHAF1A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
30 DRPAFPVKKLIQARL
327 RITKKFVKGSTEKNK
467 TLAGSCGKFAPFEIK
47 KRLNLVPKGKADDMS
49 LNLVPKGKADDMSDD
870 QGTPISLKRKSAGSM
95 RPKLVNGKGPLDNFL

Function

Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci

Protein Sequence

10 MLEELECGAP 20 GARGAATAMD 30 CKDRPAFPVK 40 KLIQARLPFK 50 RLNLVPKGKA 60 DDMSDDQGTS 70 VQSKSPDLEA 80 SLDTLENNCH 90 VGSDIDFRPK 100 LVNGKGPLDN 110 FLRNRIETSI 120 GQSTVIIDLT 130 EDSNEQPDSL 140 VDHNKLNSEA 150 SPSREAINGQ 160 REDTGDQQGL 170 LKAIQNDKLA 180 FPGETLSDIP 190 CKTEEEGVGC 200 GGAGRRGDSQ 210 ECSPRSCPEL 220 TSGPRMCPRK 230 EQDSWSEAGG 240 ILFKGKVPMV 250 VLQDILAVRP 260 PQIKSLPATP 270 QGKNMTPESE 280 VLESFPEEDS 290 VLSHSSLSSP 300 SSTSSPEGPP 310 APPKQHSSTS 320 PFPTSTPLRR 330 ITKKFVKGST 340 EKNKLRLQRD 350 QERLGKQLKL 360 RAEREEKEKL 370 KEEAKRAKEE 380 AKKKKEEEKE 390 LKEKERREKR 400 EKDEKEKAEK 410 QRLKEERRKE 420 RQEALEAKLE 430 EKRKKEEEKR 440 LREEEKRIKA 450 EKAEITRFFQ 460 KPKTPQAPKT 470 LAGSCGKFAP 480 FEIKEHMVLA 490 PRRRTAFHPD 500 LCSQLDQLLQ 510 QQSGEFSFLK 520 DLKGRQPLRS 530 GPTHVSTRNA 540 DIFNSDVVIV 550 ERGKGDGVPE 560 RRKFGRMKLL 570 QFCENHRPAY 580 WGTWNKKTAL 590 IRARDPWAQD 600 TKLLDYEVDS 610 DEEWEEEEPG 620 ESLSHSEGDD 630 DDDMGEDEDE 640 DDGFFVPHGY 650 LSEDEGVTEE 660 CADPENHKVR 670 QKLKAKEWDE 680 FLAKGKRFRV 690 LQPVKIGCVW 700 AADRDCAGDD 710 LKVLQQFAAC 720 FLETLPAQEE 730 QTPKASKRER 740 RDEQILAQLL 750 PLLHGNVNGS 760 KVIIREFQEH 770 CRRGLLSNHT 780 GSPRSPSTTY 790 LHTPTPSEDA 800 AIPSKSRLKR 810 LISENSVYEK 820 RPDFRMCWYV 830 HPQVLQSFQQ 840 EHLPVPCQWS 850 YVTSVPSAPK 860 EDSGSVPSTG 870 PSQGTPISLK 880 RKSAGSMCIT 890 QFMKKRRHDG 900 QIGAEDMDGF 910 QADTEEEEEE 920 EGDCMIVDVP 930 DAAEVQAPCG 940 AASGAGGGVG 950 VDTGKATLTA SPLGAS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0033186 CAF-1 complex
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0070087 chromo shadow domain binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0051082 unfolded protein binding
Biological Process GO:0006281 DNA repair
Biological Process GO:0006260 DNA replication
Biological Process GO:0006335 DNA replication-dependent chromatin assembly
Biological Process GO:0006334 nucleosome assembly

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.