Search Results
Overview
| Uniprot ID | Q13112 |
|---|---|
| Protein Name | Chromatin assembly factor 1 subunit B |
| Gene Name | CHAF1B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 477 | QPSSQNTKAHPSRRV |
| 494 | NTLQAWSKTTPRRIN |
Function
Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer
Protein Sequence
10
MKVITCEIAW
20
HNKEPVYSLD
30
FQHGTAGRIH
40
RLASAGVDTN
50
VRIWKVEKGP
60
DGKAIVEFLS
70
NLARHTKAVN
80
VVRFSPTGEI
90
LASGGDDAVI
100
LLWKVNDNKE
110
PEQIAFQDED
120
EAQLNKENWT
130
VVKTLRGHLE
140
DVYDICWATD
150
GNLMASASVD
160
NTAIIWDVSK
170
GQKISIFNEH
180
KSYVQGVTWD
190
PLGQYVATLS
200
CDRVLRVYSI
210
QKKRVAFNVS
220
KMLSGIGAEG
230
EARSYRMFHD
240
DSMKSFFRRL
250
SFTPDGSLLL
260
TPAGCVESGE
270
NVMNTTYVFS
280
RKNLKRPIAH
290
LPCPGKATLA
300
VRCCPVYFEL
310
RPVVETGVEL
320
MSLPYRLVFA
330
VASEDSVLLY
340
DTQQSFPFGY
350
VSNIHYHTLS
360
DISWSSDGAF
370
LAISSTDGYC
380
SFVTFEKDEL
390
GIPLKEKPVL
400
NMRTPDTAKK
410
TKSQTHRGSS
420
PGPRPVEGTP
430
ASRTQDPSSP
440
GTTPPQARQA
450
PAPTVIRDPP
460
SITPAVKSPL
470
PGPSEEKTLQ
480
PSSQNTKAHP
490
SRRVTLNTLQ
500
AWSKTTPRRI
510
NLTPLKTDTP
520
PSSVPTSVIS
530
TPSTEEIQSE
540
TPGDAQGSPP
550
ELKRPRLDEN
KGGTESLDP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0033186 | CAF-1 complex |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0042393 | histone binding |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0006260 | DNA replication |
| Biological Process | GO:0006335 | DNA replication-dependent chromatin assembly |
| Biological Process | GO:0006334 | nucleosome assembly |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.