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Overview

Uniprot IDQ13123
Protein NameProtein Red
Gene NameIK
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
137 GPTAEADKSAAEKRR
142 ADKSAAEKRRQLIQE
151 RQLIQESKFLGGDME
331 DYVPSTTKTPRDKER
408 GSTKELIKSINEKFA
501 NNKEALPKAAFQYGI
525 RFKETNDKAELDRQW
534 ELDRQWKKISAIIEK
54 PTSAPPSKSRHHEMP
541 KISAIIEKRKKMEAD
83 KKKSYYAKLRQQEIE

Function

Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:28781166). Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression (PubMed:22351768, PubMed:24252166). Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint (PubMed:22351768). Required for normal accumulation of SMU1 (PubMed:24945353)

Protein Sequence

10 MPERDSEPFS 20 NPLAPDGHDV 30 DDPHSFHQSK 40 LTNEDFRKLL 50 MTPRAAPTSA 60 PPSKSRHHEM 70 PREYNEDEDP 80 AARRRKKKSY 90 YAKLRQQEIE 100 RERELAEKYR 110 DRAKERRDGV 120 NKDYEETELI 130 STTANYRAVG 140 PTAEADKSAA 150 EKRRQLIQES 160 KFLGGDMEHT 170 HLVKGLDFAL 180 LQKVRAEIAS 190 KEKEEEELME 200 KPQKETKKDE 210 DPENKIEFKT 220 RLGRNVYRML 230 FKSKAYERNE 240 LFLPGRMAYV 250 VDLDDEYADT 260 DIPTTLIRSK 270 ADCPTMEAQT 280 TLTTNDIVIS 290 KLTQILSYLR 300 QGTRNKKLKK 310 KDKGKLEEKK 320 PPEADMNIFE 330 DIGDYVPSTT 340 KTPRDKERER 350 YRERERDRER 360 DRDRDRERER 370 ERDRERERER 380 DREREEEKKR 390 HSYFEKPKVD 400 DEPMDVDKGP 410 GSTKELIKSI 420 NEKFAGSAGW 430 EGTESLKKPE 440 DKKQLGDFFG 450 MSNSYAECYP 460 ATMDDMAVDS 470 DEEVDYSKMD 480 QGNKKGPLGR 490 WDFDTQEEYS 500 EYMNNKEALP 510 KAAFQYGIKM 520 SEGRKTRRFK 530 ETNDKAELDR 540 QWKKISAIIE 550 KRKKMEADGV EVKRPKY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000922 spindle pole
Cellular Component GO:0071005 U2-type precatalytic spliceosome
Molecular Function GO:0042802 identical protein binding
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0007094 mitotic spindle assembly checkpoint signaling
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0034501 protein localization to kinetochore

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.