Overview
| Uniprot ID | Q13126 |
|---|
| Protein Name | S-methyl-5'-thioadenosine phosphorylase |
|---|
| Gene Name | MTAP |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 49 |
SDALILGKIKNVDCV |
| 51 |
ALILGKIKNVDCVLL |
Function
Catalyzes the phosphorolytic cleavage of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose1-phosphate (PubMed:3091600, PubMed:8687427, PubMed:10404592). Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis (PubMed:3091600, PubMed:8687427, PubMed:10404592). Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine (PubMed:3091600, PubMed:8687427, PubMed:10404592). Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates (PubMed:10404592)
Protein Sequence
10
MASGTTTTAV
20
KIGIIGGTGL
30
DDPEILEGRT
40
EKYVDTPFGK
50
PSDALILGKI
60
KNVDCVLLAR
70
HGRQHTIMPS
80
KVNYQANIWA
90
LKEEGCTHVI
100
VTTACGSLRE
110
EIQPGDIVII
120
DQFIDRTTMR
130
PQSFYDGSHS
140
CARGVCHIPM
150
AEPFCPKTRE
160
VLIETAKKLG
170
LRCHSKGTMV
180
TIEGPRFSSR
190
AESFMFRTWG
200
ADVINMTTVP
210
EVVLAKEAGI
220
CYASIAMATD
230
YDCWKEHEEA
240
VSVDRVLKTL
250
KENANKAKSL
260
LLTTIPQIGS
270
TEWSETLHNL
280
KNMAQFSVLL
PRH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0004645 |
1,4-alpha-oligoglucan phosphorylase activity |
| Molecular Function |
GO:0017061 |
S-methyl-5-thioadenosine phosphorylase activity |
| Biological Process |
GO:0019509 |
L-methionine salvage from methylthioadenosine |
| Biological Process |
GO:0006139 |
nucleobase-containing compound metabolic process |
| Biological Process |
GO:0006166 |
purine ribonucleoside salvage |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.