Search Results

Overview

Uniprot IDQ13136
Protein NameLiprin-alpha-1
Gene NamePPFIA1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
756 LRLDRLHKGALHTVS

Function

May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates

Protein Sequence

10 MMCEVMPTIS 20 EAEGPPGGGG 30 GHGSGSPSQP 40 DADSHFEQLM 50 VSMLEERDRL 60 LDTLRETQET 70 LALTQGKLHE 80 VGHERDSLQR 90 QLNTALPQEF 100 AALTKELNVC 110 REQLLEREEE 120 IAELKAERNN 130 TRLLLEHLEC 140 LVSRHERSLR 150 MTVVKRQAQS 160 PAGVSSEVEV 170 LKALKSLFEH 180 HKALDEKVRE 190 RLRVALERCS 200 LLEEELGATH 210 KELMILKEQN 220 NQKKTLTDGV 230 LDINHEQENT 240 PSTSGKRSSD 250 GSLSHEEDLA 260 KVIELQEIIS 270 KQSREQSQMK 280 ERLASLSSHV 290 TELEEDLDTA 300 RKDLIKSEEM 310 NTKLQRDVRE 320 AMAQKEDMEE 330 RITTLEKRYL 340 AAQREATSVH 350 DLNDKLENEI 360 ANKDSMHRQT 370 EDKNRQLQER 380 LELAEQKLQQ 390 TLRKAETLPE 400 VEAELAQRVA 410 ALSKAEERHG 420 NIEERLRQME 430 AQLEEKNQEL 440 QRARQREKMN 450 EEHNKRLSDT 460 VDKLLSESNE 470 RLQLHLKERM 480 AALEDKNSLL 490 REVESAKKQL 500 EETQHDKDQL 510 VLNIEALRAE 520 LDHMRLRGAS 530 LHHGRPHLGS 540 VPDFRFPMAD 550 GHTDSYSTSA 560 VLRRPQKGRL 570 AALRDEPSKV 580 QTLNEQDWER 590 AQQASVLANV 600 AQAFESDADV 610 SDGEDDRDTL 620 LSSVDLLSPS 630 GQADAHTLAM 640 MLQEQLDAIN 650 KEIRLIQEEK 660 ENTEQRAEEI 670 ESRVGSGSLD 680 NLGRFRSMSS 690 IPPYPASSLA 700 SSSPPGSGRS 710 TPRRIPHSPA 720 REVDRLGVMT 730 LLPPSREEVR 740 DDKTTIKCET 750 SPPSSPRALR 760 LDRLHKGALH 770 TVSHEDIRDI 780 RNSTGSQDGP 790 VSNPSSSNSS 800 QDSLHKAPKK 810 KGIKSSIGRL 820 FGKKEKGRPG 830 QTGKEALGQA 840 GVSETDNSSQ 850 DALGLSKLGG 860 QAEKNRKLQK 870 KHELLEEARR 880 QGLPFAQWDG 890 PTVVVWLELW 900 VGMPAWYVAA 910 CRANVKSGAI 920 MSALSDTEIQ 930 REIGISNPLH 940 RLKLRLAIQE 950 IMSLTSPSAP 960 PTSRTTLAYG 970 DMNHEWIGNE 980 WLPSLGLPQY 990 RSYFMECLVD 1000 ARMLDHLTKK 1010 DLRGQLKMVD 1020 SFHRNSFQCG 1030 IMCLRRLNYD 1040 RKELERKREE 1050 SQSEIKDVLV 1060 WSNDRVIRWI 1070 LSIGLKEYAN 1080 NLIESGVHGA 1090 LLALDETFDF 1100 SALALLLQIP 1110 TQNTQARAVL 1120 EREFNNLLVM 1130 GTDRRFDEDD 1140 DKSFRRAPSW 1150 RKKFRPKDIR 1160 GLAAGSAETL 1170 PANFRVTSSM 1180 SSPSMQPKKM 1190 QMDGNVSGTQ 1200 RLDSATVRTY SC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0048786 presynaptic active zone
Biological Process GO:0007160 cell-matrix adhesion
Biological Process GO:0043622 cortical microtubule organization
Biological Process GO:1903077 negative regulation of protein localization to plasma membrane
Biological Process GO:0051497 negative regulation of stress fiber assembly
Biological Process GO:0007165 signal transduction
Biological Process GO:0050808 synapse organization

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.