Search Results

Overview

Uniprot IDQ13151
Protein NameHeterogeneous nuclear ribonucleoprotein A0
Gene NameHNRNPA0
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
133 KAEIIADKQSGKKRG
138 ADKQSGKKRGFGFVY
159 ADKAAVVKFHPIQGH
176 EVKKAVPKEDIYSGG
45 VVVNPQTKRSRCFGF
96 ARPGAHAKVKKLFVG
99 GAHAKVKKLFVGGLK

Function

mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs

Protein Sequence

10 MENSQLCKLF 20 IGGLNVQTSE 30 SGLRGHFEAF 40 GTLTDCVVVV 50 NPQTKRSRCF 60 GFVTYSNVEE 70 ADAAMAASPH 80 AVDGNTVELK 90 RAVSREDSAR 100 PGAHAKVKKL 110 FVGGLKGDVA 120 EGDLIEHFSQ 130 FGTVEKAEII 140 ADKQSGKKRG 150 FGFVYFQNHD 160 AADKAAVVKF 170 HPIQGHRVEV 180 KKAVPKEDIY 190 SGGGGGGSRS 200 SRGGRGGRGR 210 GGGRDQNGLS 220 KGGGGGYNSY 230 GGYGGGGGGG 240 YNAYGGGGGG 250 SSYGGSDYGN 260 GFGGFGSYSQ 270 HQSSYGPMKS 280 GGGGGGGGSS 290 WGGRSNSGPY 300 RGGYGGGGGY GGSSF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:1990904 ribonucleoprotein complex
Cellular Component GO:0045202 synapse
Molecular Function GO:0035925 mRNA 3'-UTR AU-rich region binding
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0070935 3'-UTR-mediated mRNA stabilization
Biological Process GO:0006954 inflammatory response
Biological Process GO:0006397 mRNA processing
Biological Process GO:0032496 response to lipopolysaccharide

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.