Search Results
Overview
| Uniprot ID | Q13162 |
|---|---|
| Protein Name | Peroxiredoxin-4 |
| Gene Name | PRDX4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 240 | QAFQYTDKHGEVCPA |
| 250 | EVCPAGWKPGSETII |
| 78 | DHSLHLSKAKISKPA |
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation
Protein Sequence
10
MEALPLLAAT
20
TPDHGRHRRL
30
LLLPLLLFLL
40
PAGAVQGWET
50
EERPRTREEE
60
CHFYAGGQVY
70
PGEASRVSVA
80
DHSLHLSKAK
90
ISKPAPYWEG
100
TAVIDGEFKE
110
LKLTDYRGKY
120
LVFFFYPLDF
130
TFVCPTEIIA
140
FGDRLEEFRS
150
INTEVVACSV
160
DSQFTHLAWI
170
NTPRRQGGLG
180
PIRIPLLSDL
190
THQISKDYGV
200
YLEDSGHTLR
210
GLFIIDDKGI
220
LRQITLNDLP
230
VGRSVDETLR
240
LVQAFQYTDK
250
HGEVCPAGWK
260
PGSETIIPDP
270
AGKLKYFDKL
N
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:1904813 | ficolin-1-rich granule lumen |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0034774 | secretory granule lumen |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0140313 | molecular sequestering activity |
| Molecular Function | GO:0008379 | thioredoxin peroxidase activity |
| Biological Process | GO:0045454 | cell redox homeostasis |
| Biological Process | GO:0042744 | hydrogen peroxide catabolic process |
| Biological Process | GO:0007252 | I-kappaB phosphorylation |
| Biological Process | GO:0006979 | response to oxidative stress |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.