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Overview

Uniprot IDQ13164
Protein NameMitogen-activated protein kinase 7
Gene NameMAPK7
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
41 AKNLALLKARSFDVT
480 DNTKAALKAALLKSL

Function

Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction

Protein Sequence

10 MAEPLKEEDG 20 EDGSAEPPGP 30 VKAEPAHTAA 40 SVAAKNLALL 50 KARSFDVTFD 60 VGDEYEIIET 70 IGNGAYGVVS 80 SARRRLTGQQ 90 VAIKKIPNAF 100 DVVTNAKRTL 110 RELKILKHFK 120 HDNIIAIKDI 130 LRPTVPYGEF 140 KSVYVVLDLM 150 ESDLHQIIHS 160 SQPLTLEHVR 170 YFLYQLLRGL 180 KYMHSAQVIH 190 RDLKPSNLLV 200 NENCELKIGD 210 FGMARGLCTS 220 PAEHQYFMTE 230 YVATRWYRAP 240 ELMLSLHEYT 250 QAIDLWSVGC 260 IFGEMLARRQ 270 LFPGKNYVHQ 280 LQLIMMVLGT 290 PSPAVIQAVG 300 AERVRAYIQS 310 LPPRQPVPWE 320 TVYPGADRQA 330 LSLLGRMLRF 340 EPSARISAAA 350 ALRHPFLAKY 360 HDPDDEPDCA 370 PPFDFAFDRE 380 ALTRERIKEA 390 IVAEIEDFHA 400 RREGIRQQIR 410 FQPSLQPVAS 420 EPGCPDVEMP 430 SPWAPSGDCA 440 MESPPPAPPP 450 CPGPAPDTID 460 LTLQPPPPVS 470 EPAPPKKDGA 480 ISDNTKAALK 490 AALLKSLRSR 500 LRDGPSAPLE 510 APEPRKPVTA 520 QERQREREEK 530 RRRRQERAKE 540 REKRRQERER 550 KERGAGASGG 560 PSTDPLAGLV 570 LSDNDRSLLE 580 RWTRMARPAA 590 PALTSVPAPA 600 PAPTPTPTPV 610 QPTSPPPGPV 620 AQPTGPQPQS 630 AGSTSGPVPQ 640 PACPPPGPAP 650 HPTGPPGPIP 660 VPAPPQIATS 670 TSLLAAQSLV 680 PPPGLPGSST 690 PGVLPYFPPG 700 LPPPDAGGAP 710 QSSMSESPDV 720 NLVTQQLSKS 730 QVEDPLPPVF 740 SGTPKGSGAG 750 YGVGFDLEEF 760 LNQSFDMGVA 770 DGPQDGQADS 780 ASLSASLLAD 790 WLEGHGMNPA 800 DIESLQREIQ 810 MDSPMLLADL PDLQDP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0016605 PML body
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004857 enzyme inhibitor activity
Molecular Function GO:0004707 MAP kinase activity
Molecular Function GO:0051019 mitogen-activated protein kinase binding
Molecular Function GO:0106310 protein serine kinase activity
Molecular Function GO:0004674 protein serine/threonine kinase activity
Biological Process GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Process GO:0030154 cell differentiation
Biological Process GO:0071363 cellular response to growth factor stimulus
Biological Process GO:0070301 cellular response to hydrogen peroxide
Biological Process GO:0071499 cellular response to laminar fluid shear stress
Biological Process GO:0071560 cellular response to transforming growth factor beta stimulus
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0000165 MAPK cascade
Biological Process GO:2000352 negative regulation of endothelial cell apoptotic process
Biological Process GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Biological Process GO:0034115 negative regulation of heterotypic cell-cell adhesion
Biological Process GO:0050728 negative regulation of inflammatory response
Biological Process GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Biological Process GO:0060761 negative regulation of response to cytokine stimulus
Biological Process GO:0034392 negative regulation of smooth muscle cell apoptotic process
Biological Process GO:0051247 positive regulation of protein metabolic process
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0007165 signal transduction

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.