Search Results
Overview
| Uniprot ID | Q13190 |
|---|---|
| Protein Name | Syntaxin-5 |
| Gene Name | STX5 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 10 | PRKRYGSKNTDQGVY |
| 122 | LTILAKRKSLFDDKA |
Function
Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus
Protein Sequence
10
MIPRKRYGSK
20
NTDQGVYLGL
30
SKTQVLSPAT
40
AGSSSSDIAP
50
LPPPVTLVPP
60
PPDTMSCRDR
70
TQEFLSACKS
80
LQTRQNGIQT
90
NKPALRAVRQ
100
RSEFTLMAKR
110
IGKDLSNTFA
120
KLEKLTILAK
130
RKSLFDDKAV
140
EIEELTYIIK
150
QDINSLNKQI
160
AQLQDFVRAK
170
GSQSGRHLQT
180
HSNTIVVSLQ
190
SKLASMSNDF
200
KSVLEVRTEN
210
LKQQRSRREQ
220
FSRAPVSALP
230
LAPNHLGGGA
240
VVLGAESHAS
250
KDVAIDMMDS
260
RTSQQLQLID
270
EQDSYIQSRA
280
DTMQNIESTI
290
VELGSIFQQL
300
AHMVKEQEET
310
IQRIDENVLG
320
AQLDVEAAHS
330
EILKYFQSVT
340
SNRWLMVKIF
350
LILIVFFIIF
VVFLA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0048278 | vesicle docking |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0012505 | endomembrane system |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane |
| Cellular Component | GO:0012507 | ER to Golgi transport vesicle membrane |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0031201 | SNARE complex |
| Cellular Component | GO:0031982 | vesicle |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0005484 | SNAP receptor activity |
| Molecular Function | GO:0000149 | SNARE binding |
| Biological Process | GO:0034498 | early endosome to Golgi transport |
| Biological Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Biological Process | GO:0090166 | Golgi disassembly |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0045732 | positive regulation of protein catabolic process |
| Biological Process | GO:1903358 | regulation of Golgi organization |
| Biological Process | GO:0042147 | retrograde transport, endosome to Golgi |
| Biological Process | GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| Biological Process | GO:0006906 | vesicle fusion |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.