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Overview

Uniprot IDQ13200
Protein Name26S proteasome non-ATPase regulatory subunit 2
Gene NamePSMD2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
623 CSEHFDSKEKEEDKD
858 DVVGQAGKPKTITGF
860 VGQAGKPKTITGFQT

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair

Protein Sequence

10 MEEGGRDKAP 20 VQPQQSPAAA 30 PGGTDEKPSG 40 KERRDAGDKD 50 KEQELSEEDK 60 QLQDELEMLV 70 ERLGEKDTSL 80 YRPALEELRR 90 QIRSSTTSMT 100 SVPKPLKFLR 110 PHYGKLKEIY 120 ENMAPGENKR 130 FAADIISVLA 140 MTMSGERECL 150 KYRLVGSQEE 160 LASWGHEYVR 170 HLAGEVAKEW 180 QELDDAEKVQ 190 REPLLTLVKE 200 IVPYNMAHNA 210 EHEACDLLME 220 IEQVDMLEKD 230 IDENAYAKVC 240 LYLTSCVNYV 250 PEPENSALLR 260 CALGVFRKFS 270 RFPEALRLAL 280 MLNDMELVED 290 IFTSCKDVVV 300 QKQMAFMLGR 310 HGVFLELSED 320 VEEYEDLTEI 330 MSNVQLNSNF 340 LALARELDIM 350 EPKVPDDIYK 360 THLENNRFGG 370 SGSQVDSARM 380 NLASSFVNGF 390 VNAAFGQDKL 400 LTDDGNKWLY 410 KNKDHGMLSA 420 AASLGMILLW 430 DVDGGLTQID 440 KYLYSSEDYI 450 KSGALLACGI 460 VNSGVRNECD 470 PALALLSDYV 480 LHNSNTMRLG 490 SIFGLGLAYA 500 GSNREDVLTL 510 LLPVMGDSKS 520 SMEVAGVTAL 530 ACGMIAVGSC 540 NGDVTSTILQ 550 TIMEKSETEL 560 KDTYARWLPL 570 GLGLNHLGKG 580 EAIEAILAAL 590 EVVSEPFRSF 600 ANTLVDVCAY 610 AGSGNVLKVQ 620 QLLHICSEHF 630 DSKEKEEDKD 640 KKEKKDKDKK 650 EAPADMGAHQ 660 GVAVLGIALI 670 AMGEEIGAEM 680 ALRTFGHLLR 690 YGEPTLRRAV 700 PLALALISVS 710 NPRLNILDTL 720 SKFSHDADPE 730 VSYNSIFAMG 740 MVGSGTNNAR 750 LAAMLRQLAQ 760 YHAKDPNNLF 770 MVRLAQGLTH 780 LGKGTLTLCP 790 YHSDRQLMSQ 800 VAVAGLLTVL 810 VSFLDVRNII 820 LGKSHYVLYG 830 LVAAMQPRML 840 VTFDEELRPL 850 PVSVRVGQAV 860 DVVGQAGKPK 870 TITGFQTHTT 880 PVLLAHGERA 890 ELATEEFLPV 900 TPILEGFVIL RKNPNYDL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:1904813 ficolin-1-rich granule lumen
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0022624 proteasome accessory complex
Cellular Component GO:0000502 proteasome complex
Cellular Component GO:0005838 proteasome regulatory particle
Cellular Component GO:0008540 proteasome regulatory particle, base subcomplex
Cellular Component GO:0034515 proteasome storage granule
Cellular Component GO:0034774 secretory granule lumen
Cellular Component GO:0008021 synaptic vesicle
Molecular Function GO:0030234 enzyme regulator activity
Biological Process GO:0071357 cellular response to type I interferon
Biological Process GO:0010498 proteasomal protein catabolic process
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0061136 regulation of proteasomal protein catabolic process
Biological Process GO:0006979 response to oxidative stress

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.