Search Results

Overview

Uniprot IDQ13206
Protein NameProbable ATP-dependent RNA helicase DDX10
Gene NameDDX10
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
555 FRAYFNEKMSILQKG
561 EKMSILQKGGKRLEG
657 DEKTLQKKEPSKSSI
670 SIKKKMTKVAEAKKV
724 TGGINLHKAKERLQE

Function

Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilizing its protein level (PubMed:32519665). Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression (PubMed:36779599)

Protein Sequence

10 MGKTANSPGS 20 GARPDPVRSF 30 NRWKKKHSHR 40 QNKKKQLRKQ 50 LKKPEWQVER 60 ESISRLMQNY 70 EKINVNEITR 80 FSDFPLSKKT 90 LKGLQEAQYR 100 LVTEIQKQTI 110 GLALQGKDVL 120 GAAKTGSGKT 130 LAFLVPVLEA 140 LYRLQWTSTD 150 GLGVLIISPT 160 RELAYQTFEV 170 LRKVGKNHDF 180 SAGLIIGGKD 190 LKHEAERINN 200 INILVCTPGR 210 LLQHMDETVS 220 FHATDLQMLV 230 LDEADRILDM 240 GFADTMNAVI 250 ENLPKKRQTL 260 LFSATQTKSV 270 KDLARLSLKN 280 PEYVWVHEKA 290 KYSTPATLEQ 300 NYIVCELQQK 310 ISVLYSFLRS 320 HLKKKSIVFF 330 SSCKEVQYLY 340 RVFCRLRPGV 350 SILALHGRQQ 360 QMRRMEVYNE 370 FVRKRAAVLF 380 ATDIAARGLD 390 FPAVNWVLQF 400 DCPEDANTYI 410 HRAGRTARYK 420 EDGEALLILL 430 PSEKAMVQQL 440 LQKKVPVKEI 450 KINPEKLIDV 460 QKKLESILAQ 470 DQDLKERAQR 480 CFVSYVRSVY 490 LMKDKEVFDV 500 SKLPIPEYAL 510 SLGLAVAPRV 520 RFLQKMQKQP 530 TKELVRSQAD 540 KVIEPRAPSL 550 TNDEVEEFRA 560 YFNEKMSILQ 570 KGGKRLEGTE 580 HRQDNDTGNE 590 EQEEEEDDEE 600 EMEEKLAKAK 610 GSQAPSLPNT 620 SEAQKIKEVP 630 TQFLDRDEEE 640 EDADFLKVKR 650 HNVFGLDLKD 660 EKTLQKKEPS 670 KSSIKKKMTK 680 VAEAKKVMKR 690 NFKVNKKITF 700 TDEGELVQQW 710 PQMQKSAIKD 720 AEEDDDTGGI 730 NLHKAKERLQ 740 EEDKFDKEEY 750 RKKIKAKHRE 760 KRLKEREARR 770 EANKRQAKAK 780 DEEEAFLDWS 790 DDDDDDDDGF 800 DPSTLPDPDK 810 YRSSEDSDSE 820 DMENKISDTK 830 KKQGMKKRSN 840 SEVEDVGPTS 850 HNRKKARWDT 860 LEPLDTGLSL 870 AEDEELVLHL LRSQS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003724 RNA helicase activity
Biological Process GO:0006364 rRNA processing

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.