Search Results
Overview
| Uniprot ID | Q13217 |
|---|---|
| Protein Name | DnaJ homolog subfamily C member 3 |
| Gene Name | DNAJC3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 318 | RICHCFSKDEKPVEA |
Function
Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity
Protein Sequence
10
MVAPGSVTSR
20
LGSVFPFLLV
30
LVDLQYEGAE
40
CGVNADVEKH
50
LELGKKLLAA
60
GQLADALSQF
70
HAAVDGDPDN
80
YIAYYRRATV
90
FLAMGKSKAA
100
LPDLTKVIQL
110
KMDFTAARLQ
120
RGHLLLKQGK
130
LDEAEDDFKK
140
VLKSNPSENE
150
EKEAQSQLIK
160
SDEMQRLRSQ
170
ALNAFGSGDY
180
TAAIAFLDKI
190
LEVCVWDAEL
200
RELRAECFIK
210
EGEPRKAISD
220
LKAASKLKND
230
NTEAFYKIST
240
LYYQLGDHEL
250
SLSEVRECLK
260
LDQDHKRCFA
270
HYKQVKKLNK
280
LIESAEELIR
290
DGRYTDATSK
300
YESVMKTEPS
310
IAEYTVRSKE
320
RICHCFSKDE
330
KPVEAIRVCS
340
EVLQMEPDNV
350
NALKDRAEAY
360
LIEEMYDEAI
370
QDYETAQEHN
380
ENDQQIREGL
390
EKAQRLLKQS
400
QKRDYYKILG
410
VKRNAKKQEI
420
IKAYRKLALQ
430
WHPDNFQNEE
440
EKKKAEKKFI
450
DIAAAKEVLS
460
DPEMRKKFDD
470
GEDPLDAESQ
480
QGGGGNPFHR
490
SWNSWQGFNP
500
FSSGGPFRFK
FHFN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035578 | azurophil granule lumen |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:1903561 | extracellular vesicle |
| Cellular Component | GO:0016020 | membrane |
| Molecular Function | GO:0051787 | misfolded protein binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0004860 | protein kinase inhibitor activity |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Biological Process | GO:0070417 | cellular response to cold |
| Biological Process | GO:0051607 | defense response to virus |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:1903912 | negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation |
| Biological Process | GO:1902010 | negative regulation of translation in response to endoplasmic reticulum stress |
| Biological Process | GO:0036494 | positive regulation of translation initiation in response to endoplasmic reticulum stress |
| Biological Process | GO:0034975 | protein folding in endoplasmic reticulum |
| Biological Process | GO:0051603 | proteolysis involved in protein catabolic process |
| Biological Process | GO:0006986 | response to unfolded protein |
Reference
PMID: N/A