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Overview

Uniprot ID	Q13228
Protein Name	Methanethiol oxidase
Gene Name	SELENBP1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
120	PRAPKLHKVIEPKDI
125	LHKVIEPKDIHAKCE
279	STIQRFYKNEGGTWS
289	GGTWSVEKVIQVPPK
379	QPEPLVVKGKRVAGG
397	IQLSLDGKRLYITTS
4	****MATKCGNCGPG
52	ATVDVDPKSPQYCQV
93	DSTKSRTKLVLPSLI

Function

Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (PubMed:29255262). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity)

Protein Sequence

10 MATKCGNCGP 20 GYSTPLEAMK 30 GPREEIVYLP 40 CIYRNTGTEA 50 PDYLATVDVD 60 PKSPQYCQVI 70 HRLPMPNLKD 80 ELHHSGWNTC 90 SSCFGDSTKS 100 RTKLVLPSLI 110 SSRIYVVDVG 120 SEPRAPKLHK 130 VIEPKDIHAK 140 CELAFLHTSH 150 CLASGEVMIS 160 SLGDVKGNGK 170 GGFVLLDGET 180 FEVKGTWERP 190 GGAAPLGYDF 200 WYQPRHNVMI 210 STEWAAPNVL 220 RDGFNPADVE 230 AGLYGSHLYV 240 WDWQRHEIVQ 250 TLSLKDGLIP 260 LEIRFLHNPD 270 AAQGFVGCAL 280 SSTIQRFYKN 290 EGGTWSVEKV 300 IQVPPKKVKG 310 WLLPEMPGLI 320 TDILLSLDDR 330 FLYFSNWLHG 340 DLRQYDISDP 350 QRPRLTGQLF 360 LGGSIVKGGP 370 VQVLEDEELK 380 SQPEPLVVKG 390 KRVAGGPQMI 400 QLSLDGKRLY 410 ITTSLYSAWD 420 KQFYPDLIRE 430 GSVMLQVDVD 440 TVKGGLKLNP 450 NFLVDFGKEP 460 LGPALAHELR 470 YPGGDCSSDI WI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005730	nucleolus
Molecular Function	GO:0018549	methanethiol oxidase activity
Molecular Function	GO:0008430	selenium binding
Biological Process	GO:0015031	protein transport

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.