Search Results
Overview
| Uniprot ID | Q13243 |
|---|---|
| Protein Name | Serine/arginine-rich splicing factor 5 |
| Gene Name | SRSF5 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 175 | EINGRKIKLIEGSKR |
| 25 | KDVERFFKGYGRIRD |
Function
Plays a role in constitutive splicing and can modulate the selection of alternative splice sites
Protein Sequence
10
MSGCRVFIGR
20
LNPAAREKDV
30
ERFFKGYGRI
40
RDIDLKRGFG
50
FVEFEDPRDA
60
DDAVYELDGK
70
ELCSERVTIE
80
HARARSRGGR
90
GRGRYSDRFS
100
SRRPRNDRRN
110
APPVRTENRL
120
IVENLSSRVS
130
WQDLKDFMRQ
140
AGEVTFADAH
150
RPKLNEGVVE
160
FASYGDLKNA
170
IEKLSGKEIN
180
GRKIKLIEGS
190
KRHSRSRSRS
200
RSRTRSSSRS
210
RSRSRSRSRK
220
SYSRSRSRSR
230
SRSRSKSRSV
240
SRSPVPEKSQ
250
KRGSSSRSKS
260
PASVDRQRSR
270
SRSRSRSVDS
GN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0043422 | protein kinase B binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0032869 | cellular response to insulin stimulus |
| Biological Process | GO:0097421 | liver regeneration |
| Biological Process | GO:0006397 | mRNA processing |
| Biological Process | GO:0006376 | mRNA splice site recognition |
| Biological Process | GO:0033120 | positive regulation of RNA splicing |
| Biological Process | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.