Search Results

Overview

Uniprot IDQ13268
Protein NameDehydrogenase/reductase SDR family member 2, mitochondrial
Gene NameDHRS2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
206 LALELAPKDIRVNCV
224 IIKTDFSKVFHGNES
234 HGNESLWKNFKEHHQ
237 ESLWKNFKEHHQLQR
31 SSTGIDRKGVLANRV
69 HVVISSRKQQNVDRA
79 NVDRAMAKLQGEGLS
96 GIVCHVGKAEDREQL

Function

NADPH-dependent oxidoreductase which catalyzes the reduction of dicarbonyl compounds. Displays reductase activity in vitro with 3,4-hexanedione, 2,3-heptanedione and 1-phenyl-1,2-propanedione as substrates (PubMed:16685466). May function as a dicarbonyl reductase in the enzymatic inactivation of reactive carbonyls involved in covalent modification of cellular components (PubMed:16685466). Also displays a minor hydroxysteroid dehydrogenase activity toward bile acids such as ursodeoxycholic acid (UDCA) and isoursodeoxycholic acid (isoUDCA), which makes it unlikely to control hormone levels (PubMed:16685466). Doesn't show any activity in vitro with retinoids and sugars as substrates (PubMed:16685466). Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21 (PubMed:20547751). Reduces proliferation, migration and invasion of cancer cells and well as the production of ROS in cancer (PubMed:29106393)

Protein Sequence

10 MLSAVARGYQ 20 GWFHPCARLS 30 VRMSSTGIDR 40 KGVLANRVAV 50 VTGSTSGIGF 60 AIARRLARDG 70 AHVVISSRKQ 80 QNVDRAMAKL 90 QGEGLSVAGI 100 VCHVGKAEDR 110 EQLVAKALEH 120 CGGVDFLVCS 130 AGVNPLVGST 140 LGTSEQIWDK 150 ILSVNVKSPA 160 LLLSQLLPYM 170 ENRRGAVILV 180 SSIAAYNPVV 190 ALGVYNVSKT 200 ALLGLTRTLA 210 LELAPKDIRV 220 NCVVPGIIKT 230 DFSKVFHGNE 240 SLWKNFKEHH 250 QLQRIGESED 260 CAGIVSFLCS 270 PDASYVNGEN 280 IAVAGYSTRL

Gene Ontology

Classification GO ID Description
Biological Process GO:0009636 response to toxic substance
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005635 nuclear envelope
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0004090 carbonyl reductase (NADPH) activity
Molecular Function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process GO:0008207 C21-steroid hormone metabolic process
Biological Process GO:0034599 cellular response to oxidative stress
Biological Process GO:0022900 electron transport chain
Biological Process GO:0043011 myeloid dendritic cell differentiation
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0008285 negative regulation of cell population proliferation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.