Search Results
Overview
| Uniprot ID | Q13310 |
|---|---|
| Protein Name | Polyadenylate-binding protein 4 |
| Gene Name | PABPC4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 629 | VLQAHHAKKEAAQKV |
| 630 | LQAHHAKKEAAQKVG |
| 635 | AKKEAAQKVGAVAAA |
| 95 | QRDPSLRKSGVGNVF |
Function
Binds the poly(A) tail of mRNA (PubMed:8524242). Binds to SMIM26 mRNA and plays a role in its post-transcriptional regulation (PubMed:37009826). May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity)
Protein Sequence
10
MNAAASSYPM
20
ASLYVGDLHS
30
DVTEAMLYEK
40
FSPAGPVLSI
50
RVCRDMITRR
60
SLGYAYVNFQ
70
QPADAERALD
80
TMNFDVIKGK
90
PIRIMWSQRD
100
PSLRKSGVGN
110
VFIKNLDKSI
120
DNKALYDTFS
130
AFGNILSCKV
140
VCDENGSKGY
150
AFVHFETQEA
160
ADKAIEKMNG
170
MLLNDRKVFV
180
GRFKSRKERE
190
AELGAKAKEF
200
TNVYIKNFGE
210
EVDDESLKEL
220
FSQFGKTLSV
230
KVMRDPNGKS
240
KGFGFVSYEK
250
HEDANKAVEE
260
MNGKEISGKI
270
IFVGRAQKKV
280
ERQAELKRKF
290
EQLKQERISR
300
YQGVNLYIKN
310
LDDTIDDEKL
320
RKEFSPFGSI
330
TSAKVMLEDG
340
RSKGFGFVCF
350
SSPEEATKAV
360
TEMNGRIVGS
370
KPLYVALAQR
380
KEERKAHLTN
390
QYMQRVAGMR
400
ALPANAILNQ
410
FQPAAGGYFV
420
PAVPQAQGRP
430
PYYTPNQLAQ
440
MRPNPRWQQG
450
GRPQGFQGMP
460
SAIRQSGPRP
470
TLRHLAPTGS
480
ECPDRLAMDF
490
GGAGAAQQGL
500
TDSCQSGGVP
510
TAVQNLAPRA
520
AVAAAAPRAV
530
APYKYASSVR
540
SPHPAIQPLQ
550
APQPAVHVQG
560
QEPLTASMLA
570
AAPPQEQKQM
580
LGERLFPLIQ
590
TMHSNLAGKI
600
TGMLLEIDNS
610
ELLHMLESPE
620
SLRSKVDEAV
630
AVLQAHHAKK
640
EAAQKVGAVA
AATS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0010494 | cytoplasmic stress granule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Molecular Function | GO:0003730 | mRNA 3'-UTR binding |
| Molecular Function | GO:0008143 | poly(A) binding |
| Molecular Function | GO:0008266 | poly(U) RNA binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0007596 | blood coagulation |
| Biological Process | GO:0006401 | RNA catabolic process |
| Biological Process | GO:0006396 | RNA processing |
| Biological Process | GO:0006412 | translation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.