Search Results
Overview
| Uniprot ID | Q13336 |
|---|---|
| Protein Name | Urea transporter 1 |
| Gene Name | SLC14A1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 50 | KELANQLKDKPVVLQ |
| 52 | LANQLKDKPVVLQFI |
Function
Mediates the transport of urea driven by a concentration gradient across the cell membrane of erythrocytes (PubMed:10514515, PubMed:7797558, PubMed:7989337, PubMed:8997401). Also mediates the transport of urea across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism (By similarity). Facilitates water transport in erythrocytes (By similarity)
Protein Sequence
10
MEDSPTMVRV
20
DSPTMVRGEN
30
QVSPCQGRRC
40
FPKALGYVTG
50
DMKELANQLK
60
DKPVVLQFID
70
WILRGISQVV
80
FVNNPVSGIL
90
ILVGLLVQNP
100
WWALTGWLGT
110
VVSTLMALLL
120
SQDRSLIASG
130
LYGYNATLVG
140
VLMAVFSDKG
150
DYFWWLLLPV
160
CAMSMTCPIF
170
SSALNSMLSK
180
WDLPVFTLPF
190
NMALSMYLSA
200
TGHYNPFFPA
210
KLVIPITTAP
220
NISWSDLSAL
230
ELLKSIPVGV
240
GQIYGCDNPW
250
TGGIFLGAIL
260
LSSPLMCLHA
270
AIGSLLGIAA
280
GLSLSAPFED
290
IYFGLWGFNS
300
SLACIAMGGM
310
FMALTWQTHL
320
LALGCALFTA
330
YLGVGMANFM
340
AEVGLPACTW
350
PFCLATLLFL
360
IMTTKNSNIY
370
KMPLSKVTYP
380
EENRIFYLQA
KKRMVESPL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0015265 | urea channel activity |
| Molecular Function | GO:0015204 | urea transmembrane transporter activity |
| Molecular Function | GO:0005372 | water transmembrane transporter activity |
| Biological Process | GO:0015837 | amine transport |
| Biological Process | GO:0071918 | urea transmembrane transport |
| Biological Process | GO:0015840 | urea transport |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.