Overview
| Uniprot ID | Q13352 |
|---|
| Protein Name | Centromere protein R |
|---|
| Gene Name | ITGB3BP |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 66 |
LSNEKRKKLNHPSLT |
Function
Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex
Protein Sequence
10
MPVKRSLKLD
20
GLLEENSFDP
30
SKITRKKSVI
40
TYSPTTGTCQ
50
MSLFASPTSS
60
EEQKHRNGLS
70
NEKRKKLNHP
80
SLTESKESTT
90
KDNDEFMMLL
100
SKVEKLSEEI
110
MEIMQNLSSI
120
QALEGSRELE
130
NLIGISCASH
140
FLKREMQKTK
150
ELMTKVNKQK
160
LFEKSTGLPH
170
KASRHLDSYE
FLKAILN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0000776 |
kinetochore |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0007155 |
cell adhesion |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0034080 |
CENP-A containing chromatin assembly |
| Biological Process |
GO:0007059 |
chromosome segregation |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0006355 |
regulation of DNA-templated transcription |
| Biological Process |
GO:0007165 |
signal transduction |
Reference
PMID: N/A