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Overview

Uniprot IDQ13356
Protein NameRING-type E3 ubiquitin-protein ligase PPIL2
Gene NamePPIL2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
235 PEKKKVDKLNAAHYS
454 QERKTQLKVAPETKV
462 VAPETKVKSSQPQAG
482 TFRQGVGKYINPAAT
490 YINPAATKRAAEEEP
507 SATVPMSKKKPSRGF
508 ATVPMSKKKPSRGFG

Function

Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423). May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance (PubMed:15946952). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable)

Protein Sequence

10 MGKRQHQKDK 20 MYITCAEYTH 30 FYGGKKPDLP 40 QTNFRRLPFD 50 HCSLSLQPFV 60 YPVCTPDGIV 70 FDLLNIVPWL 80 KKYGTNPSNG 90 EKLDGRSLIK 100 LNFSKNSEGK 110 YHCPVLFTVF 120 TNNTHIVAVR 130 TTGNVYAYEA 140 VEQLNIKAKN 150 FRDLLTDEPF 160 SRQDIITLQD 170 PTNLDKFNVS 180 NFYHVKNNMK 190 IIDPDEEKAK 200 QDPSYYLKNT 210 NAETRETLQE 220 LYKEFKGDEI 230 LAATMKAPEK 240 KKVDKLNAAH 250 YSTGKVSASF 260 TSTAMVPETT 270 HEAAAIDEDV 280 LRYQFVKKKG 290 YVRLHTNKGD 300 LNLELHCDLT 310 PKTCENFIRL 320 CKKHYYDGTI 330 FHRSIRNFVI 340 QGGDPTGTGT 350 GGESYWGKPF 360 KDEFRPNLSH 370 TGRGILSMAN 380 SGPNSNRSQF 390 FITFRSCAYL 400 DKKHTIFGRV 410 VGGFDVLTAM 420 ENVESDPKTD 430 RPKEEIRIDA 440 TTVFVDPYEE 450 ADAQIAQERK 460 TQLKVAPETK 470 VKSSQPQAGS 480 QGPQTFRQGV 490 GKYINPAATK 500 RAAEEEPSTS 510 ATVPMSKKKP 520 SRGFGDFSSW

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071013 catalytic step 2 spliceosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005796 Golgi lumen
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0061630 ubiquitin protein ligase activity
Molecular Function GO:0034450 ubiquitin-ubiquitin ligase activity
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0006457 protein folding
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0000209 protein polyubiquitination

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.