Search Results

Overview

Uniprot ID	Q13362
Protein Name	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Gene Name	PPP2R5C
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
496	DRPLARRKSELPQDP

Function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation

Protein Sequence

10 MLTCNKAGSR 20 MVVDAANSNG 30 PFQPVVLLHI 40 RDVPPADQEK 50 LFIQKLRQCC 60 VLFDFVSDPL 70 SDLKWKEVKR 80 AALSEMVEYI 90 THNRNVITEP 100 IYPEVVHMFA 110 VNMFRTLPPS 120 SNPTGAEFDP 130 EEDEPTLEAA 140 WPHLQLVYEF 150 FLRFLESPDF 160 QPNIAKKYID 170 QKFVLQLLEL 180 FDSEDPRERD 190 FLKTTLHRIY 200 GKFLGLRAYI 210 RKQINNIFYR 220 FIYETEHHNG 230 IAELLEILGS 240 IINGFALPLK 250 EEHKIFLLKV 260 LLPLHKVKSL 270 SVYHPQLAYC 280 VVQFLEKDST 290 LTEPVVMALL 300 KYWPKTHSPK 310 EVMFLNELEE 320 ILDVIEPSEF 330 VKIMEPLFRQ 340 LAKCVSSPHF 350 QVAERALYYW 360 NNEYIMSLIS 370 DNAAKILPIM 380 FPSLYRNSKT 390 HWNKTIHGLI 400 YNALKLFMEM 410 NQKLFDDCTQ 420 QFKAEKLKEK 430 LKMKEREEAW 440 VKIENLAKAN 450 PQYTVYSQAS 460 TMSIPVAMET 470 DGPLFEDVQM 480 LRKTVKDEAH 490 QAQKDPKKDR 500 PLARRKSELP 510 QDPHTKKALE 520 AHCRADELAS QDGR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000775	chromosome, centromeric region
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0000159	protein phosphatase type 2A complex
Molecular Function	GO:0072542	protein phosphatase activator activity
Molecular Function	GO:0019888	protein phosphatase regulator activity
Biological Process	GO:0030330	DNA damage response, signal transduction by p53 class mediator
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Biological Process	GO:0051177	meiotic sister chromatid cohesion
Biological Process	GO:0008285	negative regulation of cell population proliferation
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process	GO:0007165	signal transduction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.