Search Results
Overview
| Uniprot ID | Q13393 |
|---|---|
| Protein Name | Phospholipase D1 |
| Gene Name | PLD1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 708 | WNFTKIMKSKYRSLS |
| 807 | AIAQRILKAHRENQK |
Function
Function as phospholipase selective for phosphatidylcholine (PubMed:25936805, PubMed:8530346, PubMed:9582313). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity)
Protein Sequence
10
MSLKNEPRVN
20
TSALQKIAAD
30
MSNIIENLDT
40
RELHFEGEEV
50
DYDVSPSDPK
60
IQEVYIPFSA
70
IYNTQGFKEP
80
NIQTYLSGCP
90
IKAQVLEVER
100
FTSTTRVPSI
110
NLYTIELTHG
120
EFKWQVKRKF
130
KHFQEFHREL
140
LKYKAFIRIP
150
IPTRRHTFRR
160
QNVREEPREM
170
PSLPRSSENM
180
IREEQFLGRR
190
KQLEDYLTKI
200
LKMPMYRNYH
210
ATTEFLDISQ
220
LSFIHDLGPK
230
GIEGMIMKRS
240
GGHRIPGLNC
250
CGQGRACYRW
260
SKRWLIVKDS
270
FLLYMKPDSG
280
AIAFVLLVDK
290
EFKIKVGKKE
300
TETKYGIRID
310
NLSRTLILKC
320
NSYRHARWWG
330
GAIEEFIQKH
340
GTNFLKDHRF
350
GSYAAIQENA
360
LAKWYVNAKG
370
YFEDVANAME
380
EANEEIFITD
390
WWLSPEIFLK
400
RPVVEGNRWR
410
LDCILKRKAQ
420
QGVRIFIMLY
430
KEVELALGIN
440
SEYTKRTLMR
450
LHPNIKVMRH
460
PDHVSSTVYL
470
WAHHEKLVII
480
DQSVAFVGGI
490
DLAYGRWDDN
500
EHRLTDVGSV
510
KRVTSGPSLG
520
SLPPAAMESM
530
ESLRLKDKNE
540
PVQNLPIQKS
550
IDDVDSKLKG
560
IGKPRKFSKF
570
SLYKQLHRHH
580
LHDADSISSI
590
DSTSSYFNHY
600
RSHHNLIHGL
610
KPHFKLFHPS
620
SESEQGLTRP
630
HADTGSIRSL
640
QTGVGELHGE
650
TRFWHGKDYC
660
NFVFKDWVQL
670
DKPFADFIDR
680
YSTPRMPWHD
690
IASAVHGKAA
700
RDVARHFIQR
710
WNFTKIMKSK
720
YRSLSYPFLL
730
PKSQTTAHEL
740
RYQVPGSVHA
750
NVQLLRSAAD
760
WSAGIKYHEE
770
SIHAAYVHVI
780
ENSRHYIYIE
790
NQFFISCADD
800
KVVFNKIGDA
810
IAQRILKAHR
820
ENQKYRVYVV
830
IPLLPGFEGD
840
ISTGGGNALQ
850
AIMHFNYRTM
860
CRGENSILGQ
870
LKAELGNQWI
880
NYISFCGLRT
890
HAELEGNLVT
900
ELIYVHSKLL
910
IADDNTVIIG
920
SANINDRSML
930
GKRDSEMAVI
940
VQDTETVPSV
950
MDGKEYQAGR
960
FARGLRLQCF
970
RVVLGYLDDP
980
SEDIQDPVSD
990
KFFKEVWVST
1000
AARNATIYDK
1010
VFRCLPNDEV
1020
HNLIQLRDFI
1030
NKPVLAKEDP
1040
IRAEEELKKI
1050
RGFLVQFPFY
1060
FLSEESLLPS
1070
VGTKEAIVPM
EVWT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0098981 | cholinergic synapse |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0030139 | endocytic vesicle |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0031902 | late endosome membrane |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0035579 | specific granule membrane |
| Cellular Component | GO:0070821 | tertiary granule membrane |
| Molecular Function | GO:0004630 | D-type glycerophospholipase activity |
| Molecular Function | GO:0035091 | phosphatidylinositol binding |
| Biological Process | GO:0031670 | cellular response to nutrient |
| Biological Process | GO:0006935 | chemotaxis |
| Biological Process | GO:0006654 | phosphatidic acid biosynthetic process |
| Biological Process | GO:0009395 | phospholipid catabolic process |
| Biological Process | GO:0045727 | positive regulation of translation |
| Biological Process | GO:0007265 | Ras protein signal transduction |
| Biological Process | GO:0098693 | regulation of synaptic vesicle cycle |
| Biological Process | GO:0060627 | regulation of vesicle-mediated transport |
| Biological Process | GO:0007264 | small GTPase-mediated signal transduction |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.