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Overview

Uniprot ID	Q13409
Protein Name	Cytoplasmic dynein 1 intermediate chain 2
Gene Name	DYNC1I2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
41	KKETDQKKEAVAPVQ
8	MSDKSELKAELERKK

Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:31079899). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:31079899). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (By similarity). Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity)

Protein Sequence

10 MSDKSELKAE 20 LERKKQRLAQ 30 IREEKKRKEE 40 ERKKKETDQK 50 KEAVAPVQEE 60 SDLEKKRREA 70 EALLQSMGLT 80 PESPIVFSEY 90 WVPPPMSPSS 100 KSVSTPSEAG 110 SQDSGDGAVG 120 SRTLHWDTDP 130 SVLQLHSDSD 140 LGRGPIKLGM 150 AKITQVDFPP 160 REIVTYTKET 170 QTPVMAQPKE 180 DEEEDDDVVA 190 PKPPIEPEEE 200 KTLKKDEEND 210 SKAPPHELTE 220 EEKQQILHSE 230 EFLSFFDHST 240 RIVERALSEQ 250 INIFFDYSGR 260 DLEDKEGEIQ 270 AGAKLSLNRQ 280 FFDERWSKHR 290 VVSCLDWSSQ 300 YPELLVASYN 310 NNEDAPHEPD 320 GVALVWNMKY 330 KKTTPEYVFH 340 CQSAVMSATF 350 AKFHPNLVVG 360 GTYSGQIVLW 370 DNRSNKRTPV 380 QRTPLSAAAH 390 THPVYCVNVV 400 GTQNAHNLIS 410 ISTDGKICSW 420 SLDMLSHPQD 430 SMELVHKQSK 440 AVAVTSMSFP 450 VGDVNNFVVG 460 SEEGSVYTAC 470 RHGSKAGISE 480 MFEGHQGPIT 490 GIHCHAAVGA 500 VDFSHLFVTS 510 SFDWTVKLWT 520 TKNNKPLYSF 530 EDNADYVYDV 540 MWSPTHPALF 550 ACVDGMGRLD 560 LWNLNNDTEV 570 PTASISVEGN 580 PALNRVRWTH 590 SGREIAVGDS 600 EGQIVIYDVG 610 EQIAVPRNDE 620 WARFGRTLAE 630 INANRADAEE EAATRIPA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005868	cytoplasmic dynein complex
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0001673	male germ cell nucleus
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0031982	vesicle
Molecular Function	GO:0045504	dynein heavy chain binding
Molecular Function	GO:0045503	dynein light chain binding
Molecular Function	GO:0003777	microtubule motor activity
Biological Process	GO:0007018	microtubule-based movement
Biological Process	GO:0032388	positive regulation of intracellular transport
Biological Process	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint
Biological Process	GO:0010970	transport along microtubule

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.