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Overview

Uniprot IDQ13416
Protein NameOrigin recognition complex subunit 2
Gene NameORC2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
108 KHSEKMAKLASELAK
115 KLASELAKTPQKSVS
119 ELAKTPQKSVSFSLK
140 INVPQSSKGHSASDK
147 KGHSASDKVQPKNND
155 VQPKNNDKSEFLSTA
224 VVSAPVGKETPSKRM
266 LQKLKRAKLDQQTLR
278 TLRNLLSKVSPSFSA
47 AQLLVNPKKIIKKPE
48 QLLVNPKKIIKKPEY
51 VNPKKIIKKPEYDLE
93 SATGGGNKVYSFQNR

Function

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3

Protein Sequence

10 MSKPELKEDK 20 MLEVHFVGDD 30 DVLNHILDRE 40 GGAKLKKERA 50 QLLVNPKKII 60 KKPEYDLEED 70 DQEVLKDQNY 80 VEIMGRDVQE 90 SLKNGSATGG 100 GNKVYSFQNR 110 KHSEKMAKLA 120 SELAKTPQKS 130 VSFSLKNDPE 140 ITINVPQSSK 150 GHSASDKVQP 160 KNNDKSEFLS 170 TAPRSLRKRL 180 IVPRSHSDSE 190 SEYSASNSED 200 DEGVAQEHEE 210 DTNAVIFSQK 220 IQAQNRVVSA 230 PVGKETPSKR 240 MKRDKTSDLV 250 EEYFEAHSSS 260 KVLTSDRTLQ 270 KLKRAKLDQQ 280 TLRNLLSKVS 290 PSFSAELKQL 300 NQQYEKLFHK 310 WMLQLHLGFN 320 IVLYGLGSKR 330 DLLERFRTTM 340 LQDSIHVVIN 350 GFFPGISVKS 360 VLNSITEEVL 370 DHMGTFRSIL 380 DQLDWIVNKF 390 KEDSSLELFL 400 LIHNLDSQML 410 RGEKSQQIIG 420 QLSSLHNIYL 430 IASIDHLNAP 440 LMWDHAKQSL 450 FNWLWYETTT 460 YSPYTEETSY 470 ENSLLVKQSG 480 SLPLSSLTHV 490 LRSLTPNARG 500 IFRLLIKYQL 510 DNQDNPSYIG 520 LSFQDFYQQC 530 REAFLVNSDL 540 TLRAQLTEFR 550 DHKLIRTKKG 560 TDGVEYLLIP 570 VDNGTLTDFL EKEEEEA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0000781 chromosome, telomeric region
Cellular Component GO:0000792 heterochromatin
Cellular Component GO:0000939 inner kinetochore
Cellular Component GO:0016020 membrane
Cellular Component GO:0005664 nuclear origin of replication recognition complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000808 origin recognition complex
Molecular Function GO:0003688 DNA replication origin binding
Biological Process GO:0006270 DNA replication initiation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.